Exploiting endocytic pathways to prevent bacterial toxin infection

Harper, Callista B., McCluskey, Adam, Robinson, Phillip J. and Meunier, Frederic A. (2015). Exploiting endocytic pathways to prevent bacterial toxin infection. In Daniel Ladant, Michel R. Popoff and Joseph E. Alouf (Ed.), The comprehensive sourcebook of bacterial protein toxins 4th ed. (pp. 1072-1094) Amsterdam, Netherlands: Elsevier. doi:10.1016/B978-0-12-800188-2.00040-9

Author Harper, Callista B.
McCluskey, Adam
Robinson, Phillip J.
Meunier, Frederic A.
Title of chapter Exploiting endocytic pathways to prevent bacterial toxin infection
Title of book The comprehensive sourcebook of bacterial protein toxins
Place of Publication Amsterdam, Netherlands
Publisher Elsevier
Publication Year 2015
Sub-type Chapter in reference work, encyclopaedia, manual or handbook
DOI 10.1016/B978-0-12-800188-2.00040-9
Open Access Status Not yet assessed
Edition 4th
ISBN 9780128001882
Editor Daniel Ladant
Michel R. Popoff
Joseph E. Alouf
Chapter number 37
Start page 1072
End page 1094
Total pages 23
Total chapters 39
Language eng
Abstract/Summary Many bacterial pathogens produce toxins that target intracellular molecules to alter or disrupt normal cellular function. To access the cell, these toxins often exploit endocytic pathways, recruit cellular machinery, or both to mediate their own internalization. Bacteria are becoming increasingly resistant to antibiotics, so alternatives to treat or prevent diseases caused by bacterial toxins are necessary. The advent of small molecule inhibitors, which target key proteins involved in endocytic trafficking pathways, provides an opportunity to develop these compounds as potential therapeutic inhibitors of bacterial toxicity. This chapter reviews the endocytic pathways commonly hijacked by these toxins and the drugs that are currently being developed to inhibit specific proteins involved in endocytosis. It further evaluates the feasibility of using these compounds to investigate the modalities of the endocytosis and trafficking of bacterial toxins, and the potential for the use of these drugs as therapeutics in the future.
Keyword Endocytosis
Bacterial toxins
Small molecule inhibitors
Membrane trafficking
Clathrin-mediated endocytosis (CME)
Q-Index Code BX
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Book Chapter
Collection: Queensland Brain Institute Publications
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Created: Thu, 11 Jan 2018, 11:24:29 EST by Kirstie Asmussen on behalf of Queensland Brain Institute