Evidence of directional and stabilizing selection in contemporary humans

Sanjak, Jaleal S., Sidorenko, Julia, Robinson, Matthew R., Thornton, Kevin R. and Visscher, Peter M. (2018) Evidence of directional and stabilizing selection in contemporary humans. Proceedings of the National Academy of Sciences of the United States of America, 115 1: 151-156. doi:10.1073/pnas.1707227114


Author Sanjak, Jaleal S.
Sidorenko, Julia
Robinson, Matthew R.
Thornton, Kevin R.
Visscher, Peter M.
Title Evidence of directional and stabilizing selection in contemporary humans
Journal name Proceedings of the National Academy of Sciences of the United States of America   Check publisher's open access policy
ISSN 1091-6490
0027-8424
Publication date 2018-01-02
Year available 2018
Sub-type Article (original research)
DOI 10.1073/pnas.1707227114
Open Access Status Not yet assessed
Volume 115
Issue 1
Start page 151
End page 156
Total pages 6
Place of publication Washington, DC United States
Publisher National Academy of Sciences
Language eng
Subject 1000 General
Abstract Modern molecular genetic datasets, primarily collected to study the biology of human health and disease, can be used to directly measure the action of natural selection and reveal important features of contemporary human evolution. Here we leverage the UK Biobank data to test for the presence of linear and nonlinear natural selection in a contemporary population of the United Kingdom. We obtain phenotypic and genetic evidence consistent with the action of linear/directional selection. Phenotypic evidence suggests that stabilizing selection, which acts to reduce variance in the population without necessarily modifying the population mean, is widespread and relatively weak in comparison with estimates from other species.
Keyword complex traits
natural selection
stabilizing selection
Q-Index Code C1
Q-Index Status Provisional Code
Grant ID R01 GM115564
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: HERDC Pre-Audit
Queensland Brain Institute Publications
Institute for Molecular Bioscience - Publications
 
Versions
Version Filter Type
Citation counts: Scopus Citation Count Cited 0 times in Scopus Article
Google Scholar Search Google Scholar
Created: Wed, 10 Jan 2018, 12:49:39 EST