Treatment of eight dogs with nasal tumours with a alternating doses of doxorubicin and carboplatin in conjunction with oral piroxicam

Langova, V., Mutsaers, A. J., Phillips, B. and Straw, R. (2004) Treatment of eight dogs with nasal tumours with a alternating doses of doxorubicin and carboplatin in conjunction with oral piroxicam. Australian Veterinary Journal, 82 11: 676-680. doi:10.1111/j.1751-0813.2004.tb12151.x


Author Langova, V.
Mutsaers, A. J.
Phillips, B.
Straw, R.
Title Treatment of eight dogs with nasal tumours with a alternating doses of doxorubicin and carboplatin in conjunction with oral piroxicam
Journal name Australian Veterinary Journal   Check publisher's open access policy
ISSN 0005-0423
Publication date 2004-11-01
Sub-type Article (original research)
DOI 10.1111/j.1751-0813.2004.tb12151.x
Volume 82
Issue 11
Start page 676
End page 680
Total pages 5
Editor Maureen Revington
Place of publication Australia
Publisher Australian Vet. Assoc.
Language eng
Subject C1
300501 Veterinary Medicine
780105 Biological sciences
Abstract Objective To determine the efficacy and toxicity of chemotherapy in the treatment of canine nasal tumours. Design Retrospective clinical study Procedure Eight dogs with histologically confirmed nasal tumours were staged by means of complete blood count, serum biochemical analysis, cytological analysis of fine needle aspirate of the regional lymph nodes, thoracic radiographs and computed tomography scan of the nasal cavity. All dogs were treated with alternating doses of doxorubicin, carboplatin and oral piroxicam. All dogs were monitored for side effects of chemotherapy and evaluated for response to treatment by computed tomography scan of the nasal cavity after the first four treatments. Results Complete remission was achieved in four dogs, partial remission occurred in two dogs and two had stable disease on the basis of computed tomography evaluation. There was resolution of clinical signs after one to two doses of chemotherapy in all dogs. Conclusions This chemotherapy protocol was efficacious and well tolerated in this series of eight cases of canine nasal tumours.
Keyword Tumours
Doxorubicin
Oral Piroxicam
Veterinary Sciences
Canine Nasal
Megavoltage Irradiation
Radiotherapy
Survival
Chemotherapy
Neoplasms
Therapy
Adenocarcinoma
Diagnosis
Radiation
Q-Index Code C1

 
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Created: Wed, 15 Aug 2007, 13:57:17 EST