Microglia at center stage: A comprehensive review about the versatile and unique residential macrophages of the central nervous system

Lannes, Nils, Eppler, Elisabeth, Etemad, Samar, Yotovski, Peter and Filgueira, Luis (2017) Microglia at center stage: A comprehensive review about the versatile and unique residential macrophages of the central nervous system. Oncotarget, 8 69: 114393-114413. doi:10.18632/oncotarget.23106


Author Lannes, Nils
Eppler, Elisabeth
Etemad, Samar
Yotovski, Peter
Filgueira, Luis
Title Microglia at center stage: A comprehensive review about the versatile and unique residential macrophages of the central nervous system
Journal name Oncotarget   Check publisher's open access policy
ISSN 1949-2553
Publication date 2017-12-11
Year available 2017
Sub-type Critical review of research, literature review, critical commentary
DOI 10.18632/oncotarget.23106
Open Access Status Not yet assessed
Volume 8
Issue 69
Start page 114393
End page 114413
Total pages 21
Place of publication Albany, NY United States
Publisher Impact Journals
Language eng
Subject 2730 Oncology
Abstract Microglia cells are the unique residential macrophages of the central nervous system (CNS). They have a special origin, as they derive from the embryonic yolk sac and enter the developing CNS at a very early stage. They play an important role during CNS development and adult homeostasis. They have a major contribution to adult neurogenesis and neuroinflammation. Thus, they participate in the pathogenesis of neurodegenerative diseases and contribute to aging. They play an important role in sustaining and breaking the blood-brain barrier. As innate immune cells, they contribute substantially to the immune response against infectious agents affecting the CNS. They play also a major role in the growth of tumours of the CNS. Microglia are consequently the key cell population linking the nervous and the immune system. This review covers all different aspects of microglia biology and pathology in a comprehensive way.
Keyword Brain cancer
microglia
Neurodegeneration
Neuroinflammation
Virus infection
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: UQ Centre for Clinical Research Publications
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Created: Sat, 06 Jan 2018, 11:06:19 EST