Hepatitis C Virus

Thompson, A. J., Clark, P. and Aghemo, A. (2014). Hepatitis C Virus. In Sandosh Padmanabhan (Ed.), Handbook of Pharmacogenomics and Stratified Medicine (pp. 859-877) London, UK: Academic Press. doi:10.1016/B978-0-12-386882-4.00037-2

Author Thompson, A. J.
Clark, P.
Aghemo, A.
Title of chapter Hepatitis C Virus
Title of book Handbook of Pharmacogenomics and Stratified Medicine
Place of Publication London, UK
Publisher Academic Press
Publication Year 2014
Sub-type Research book chapter (original research)
DOI 10.1016/B978-0-12-386882-4.00037-2
Open Access Status Not yet assessed
Year available 2014
ISBN 9780123868831
Editor Sandosh Padmanabhan
Chapter number 37
Start page 859
End page 877
Total pages 19
Total chapters 46
Language eng
Subjects 2700 Medicine
3000 Pharmacology, Toxicology and Pharmaceutics
Abstract/Summary In 2009, genome-wide association studies identified key roles for IL28B and ITPA polymorphisms in predicting HCV treatment outcomes using pegylated interferon╬▒ and ribavirin therapy. The IL28B polymorphism is strongly associated with antiviral efficacy of interferon-based HCV therapy, as well as with the spontaneous clearance of acute HCV infection. Very recently, it was proposed that IL28B polymorphisms actually tag a functional variant that affects the novel IFNL4 gene. Two functional ITPA variants determine the risk of ribavirin-induced hemolytic anemia. Personalized medicine is now a reality for chronic HCV patients, and IL28B genotyping has been incorporated into the clinical algorithm for individuals considering antiviral therapy.
Keyword Anemia
Inosine triphosphatase
Q-Index Code B1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Book Chapter
Collection: School of Medicine Publications
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Created: Fri, 05 Jan 2018, 22:37:37 EST