Acquired melanocytic naevus phenotypes and MC1R genotypes in Han Chinese: A cross-sectional study

Li, Xiaohong, Lee, Katie J., Duffy, David L., Xu, Dandan, Rao Basude, Madhur Eshwar, Hu, Ying, Zhang, Hang, Jagirdar, Kasturee, Soyer, H. Peter, Dong, Huiting and Sturm, Richard A. (2017) Acquired melanocytic naevus phenotypes and MC1R genotypes in Han Chinese: A cross-sectional study. PeerJ, . doi:10.7717/peerj.4168


Author Li, Xiaohong
Lee, Katie J.
Duffy, David L.
Xu, Dandan
Rao Basude, Madhur Eshwar
Hu, Ying
Zhang, Hang
Jagirdar, Kasturee
Soyer, H. Peter
Dong, Huiting
Sturm, Richard A.
Title Acquired melanocytic naevus phenotypes and MC1R genotypes in Han Chinese: A cross-sectional study
Journal name PeerJ   Check publisher's open access policy
ISSN 2167-8359
Publication date 2017-12-20
Year available 2017
Sub-type Article (original research)
DOI 10.7717/peerj.4168
Open Access Status DOI
Total pages 17
Place of publication London, United Kingdom
Publisher PeerJ
Language eng
Subject 2800 Neuroscience
1300 Biochemistry, Genetics and Molecular Biology
1100 Agricultural and Biological Sciences
Abstract Background. Early detection and treatment are the most important elements in reducing the incidence of melanoma deaths. Acquired melanocytic naevi (AMN) are well-known precursors of melanoma but most of our knowledge on the clinico- dermoscopic phenotypes of AMN is based on studies in European-background populations, particularly American and Australian populations. There has been little research in Chinese Han populations on clinico-dermoscopic variability of naevi or how naevi are affected by melanoma-linked variants of the melanocortin 1 receptor (MC1R) gene. Methods. Clinical and dermoscopic features of 448 AMN in 115 patients from the Han ethnic group in mainland China were described. Germline polymorphisms in MC1R were determined for 98 of these patients. Results. AMN were predominantly found on the head and neck. Dermoscopic patterns observed were nonspecific, reticular, globular, and parallel furrow, with most AMN having a nonspecific pattern. There were no associations between MC1R polymorphisms and clinical or dermoscopic features of AMN. Discussion. Our results provide evidence that AMN in the Han population in China have similar dermoscopic patterns to those in European populations, but are present in much lower numbers. As there were no associations between clinical or dermoscopic features of AMN and MC1R polymorphisms, further studies should focus on candidate gene associations withAMNfeatures and the risk of melanoma, with larger sample sizes and comparisons to AMN in other populations.
Keyword Acquired melanocytic naevi
Dermoscopy
Han ethnic group
Melanocortin 1 receptor
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: HERDC Pre-Audit
UQ Diamantina Institute Publications
 
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Created: Sun, 31 Dec 2017, 20:54:06 EST