Sodium Channels and Venom Peptide Pharmacology

Israel, Mathilde R., Tay, Bryan, Deuis, Jennifer R. and Vetter, Irina (2017) Sodium Channels and Venom Peptide Pharmacology. Advances in Pharmacology, 79 67-116. doi:10.1016/bs.apha.2017.01.004

Author Israel, Mathilde R.
Tay, Bryan
Deuis, Jennifer R.
Vetter, Irina
Title Sodium Channels and Venom Peptide Pharmacology
Journal name Advances in Pharmacology   Check publisher's open access policy
ISSN 1557-8925
Publication date 2017-04-08
Year available 2017
Sub-type Article (original research)
DOI 10.1016/bs.apha.2017.01.004
Open Access Status Not yet assessed
Volume 79
Start page 67
End page 116
Total pages 50
Place of publication Maryland Heights, United States
Publisher Academic Press
Language eng
Subject 3004 Pharmacology
Abstract Venomous animals including cone snails, spiders, scorpions, anemones, and snakes have evolved a myriad of components in their venoms that target the opening and/or closing of voltage-gated sodium channels to cause devastating effects on the neuromuscular systems of predators and prey. These venom peptides, through design and serendipity, have not only contributed significantly to our understanding of sodium channel pharmacology and structure, but they also represent some of the most phyla- and isoform-selective molecules that are useful as valuable tool compounds and drug leads. Here, we review our understanding of the basic function of mammalian voltage-gated sodium channel isoforms as well as the pharmacology of venom peptides that act at these key transmembrane proteins.
Keyword Conotoxins
Gating modifier toxins
Pore blockers
Scorpion toxins
Spider venom peptides
Venom peptide
Voltage-gated sodium channel
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: HERDC Pre-Audit
School of Pharmacy Publications
Institute for Molecular Bioscience - Publications
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Citation counts: Scopus Citation Count Cited 2 times in Scopus Article | Citations
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Created: Sun, 31 Dec 2017, 19:58:43 EST