Influence of Size and Shape on the Biodistribution of Nanoparticles Prepared by Polymerization-Induced Self-Assembly

Kaga, Sadik, Truong, Nghia P., Esser, Lars, Senyschyn, Danielle, Sanyal, Amitav, Sanyal, Rana, Quinn, John F., Davis, Thomas P., Kaminskas, Lisa M. and Whittaker, Michael R. (2017) Influence of Size and Shape on the Biodistribution of Nanoparticles Prepared by Polymerization-Induced Self-Assembly. Biomacromolecules, 18 12: 3963-3970. doi:10.1021/acs.biomac.7b00995

Author Kaga, Sadik
Truong, Nghia P.
Esser, Lars
Senyschyn, Danielle
Sanyal, Amitav
Sanyal, Rana
Quinn, John F.
Davis, Thomas P.
Kaminskas, Lisa M.
Whittaker, Michael R.
Title Influence of Size and Shape on the Biodistribution of Nanoparticles Prepared by Polymerization-Induced Self-Assembly
Journal name Biomacromolecules   Check publisher's open access policy
ISSN 1526-4602
Publication date 2017-09-07
Year available 2017
Sub-type Article (original research)
DOI 10.1021/acs.biomac.7b00995
Open Access Status Not yet assessed
Volume 18
Issue 12
Start page 3963
End page 3970
Total pages 8
Place of publication Washington, DC United States
Publisher American Chemical Society
Language eng
Subject 1502 Bioengineering
2502 Biomaterials
2507 Polymers and Plastics
2505 Materials Chemistry
Abstract Polymerization-induced self-assembly (PISA) is a facile one-pot synthetic technique for preparing polymeric nanoparticles with different sizes and shapes for application in a variety of fields including nanomedicine. However, the in vivo biodistribution of nanoparticles obtained by PISA still remains unclear. To address this knowledge gap, we report the synthesis, cytotoxicity, and biodistribution in an in vivo tumor-bearing mouse model of polystyrene micelles with various sizes and polystyrene filomicelles with different lengths prepared by PISA. First, a library of nanoparticles was prepared comprised of poly(glycidyl methacrylate)-b-poly(oligo(ethylene glycol) methyl ether methacrylate)-b-polystyrene polymers, and their size and morphology were tuned by varying the polystyrene block length without affecting the surface chemistry. The H) ethanolamine, and a biodistribution study was carried out in nude mice bearing HT1080 tumor xenografts 48 h after intravenous delivery. In this model, we found that small spherical polystyrene core nanoparticles with a PEG corona (diameter 21 nm) have the highest tumor accumulation when compared to the larger spherical nanoparticles (diameter 33 nm) or rodlike (diameter 37 nm, contour length 350-500 nm) or wormlike counterparts (diameter 45 nm, contour length 1-2 μm). This finding has provided critical information on the biodistribution of polystyrene core nanoparticles with a PEG corona of different sizes and shapes prepared by the PISA technique and will inform their use in medical applications.
Keyword Acid) Block-Copolymers
Tunable Morphologies
Q-Index Code C1
Q-Index Status Provisional Code
Grant ID CE140100036
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: HERDC Pre-Audit
School of Biomedical Sciences Publications
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Created: Sun, 31 Dec 2017, 15:59:45 EST