Hoof wall wound repair

Pollitt, C. C. and Daradka, M. (2004) Hoof wall wound repair. Equine Veterinary Journal, 36 3: 210-215. doi:10.2746/0425164044877189

Author Pollitt, C. C.
Daradka, M.
Title Hoof wall wound repair
Journal name Equine Veterinary Journal   Check publisher's open access policy
ISSN 0425-1644
Publication date 2004-01-01
Sub-type Article (original research)
DOI 10.2746/0425164044877189
Volume 36
Issue 3
Start page 210
End page 215
Total pages 6
Editor Peter D. Rossdale
Place of publication United Kingdom
Publisher Equine Vet Journal Ltd.
Language eng
Subject C1
300501 Veterinary Medicine
780105 Biological sciences
Formatted abstract
Reasons for performing study: Surgical stripping of the hoof wall results in a wound that heals remarkabley well. In contrast, lamellae recovering from laminitis are often deformed. Investigating lamellar wound healing may aid understanding of laminitis.

Objectives: To document temporal changes in the lamellar basement membrane (BM), dermis and epidermis after surgery.

Methods: Wall strips were made in the dorsal hoof wall midline of 6 mature horses. Immunohistochemistry was used to document changes in the basement membrane (BM) and detect proliferation of epidermal cells in lamellar tissues harvested at intervals. A conforming metal plate was screwed to the hoof wall to maintain alignment of the wound edges.

Results: Wall stripping caused lamellar tips to snap and remain behind in the dermis along with the majority of the lamellar BM and some lamellar basal cells. Three days later the BM was intact and new lamellae had been reconstructed by proliferation of surviving epidermal cells. By 5 days the surface of the stripped zone was covered with yellow epidermis that subsequently thickened and hardened. Eventually the hoof wall deficit was replaced by new wall growing down from the coronet. The conforming metal plate and post operative analgesic ensured minimal lameness.

Conclusions and potential relevance: In wall stripped lamellae the BM survives virtually intact and is used as a template for proliferating cells, from snapped-off lamellar tips, to migrate and quickly achieve repair to near normality. In laminitis epidermal dysadhesion and lamellar BM destruction occurs and lack of a functional BM template may explain the prolonged and abnormal repair of affected lamellae.
Keyword Hoof
Veterinary Sciences
Equine Hoof Wall Repair
Wall Stripping
Wound Healing
Basement Membrane
Q-Index Code C1

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Created: Wed, 15 Aug 2007, 13:50:29 EST