Vitamin A supplementation in infectious diseases: A meta-analysis

Glasziou, P. P. and Mackerras, D. E M (1993) Vitamin A supplementation in infectious diseases: A meta-analysis. British Medical Journal, 306 6874: 366-370.

Author Glasziou, P. P.
Mackerras, D. E M
Title Vitamin A supplementation in infectious diseases: A meta-analysis
Journal name British Medical Journal
ISSN 0959-8146
Publication date 1993-02-06
Sub-type Article (original research)
Open Access Status Not yet assessed
Volume 306
Issue 6874
Start page 366
End page 370
Total pages 5
Language eng
Subject 2700 Medicine
Abstract Objective - To study the effect of vitamin A supplementation on morbidity and mortality from infectious disease. Design - A meta-analysis aimed at identifying and combining mortality and morbidity data from all randomised controlled trials of vitamin A. Results - Of 20 controlled trials identified, 12 trials were randomised trials and provided "intention to treat" data: six community trials in developing countries, three in children admitted to hospital with measles, and three in very low birth weight infants. Combined results for community studies suggest a reduction of 30% (95% confidence interval 21% to 38%; two tailed p < 0·0000001) in all cause mortality. Analysis of cause specific mortality showed a reduction in deaths from diarrhoeal disease (in community studies) by 39% (24% to 50%; two tailed p < 0·00001); from respiratory disease (in measles studies) by 70% (15% to 90%; two tailed p=0-02); and from other causes of death (in community studies) by 34% (15% to 48%; two tailed P=0·001). Reductions in morbidity were consistent with the findings for mortality, but fewer data were available. Conclusions - Adequate supply of vitamin A, either through supplementation or adequate diet, has a major role in preventing morbidity and mortality in children in developing countries. In developed countries vitamin A may also have a role in those with life threatening infections such as measles and those who may have a relative deficiency, such as premature infants.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: Scopus Import - Archived
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Created: Fri, 29 Dec 2017, 07:30:35 EST