The developmental multiplicity and isoenzyme status of cavian esterases

Holmes, R. S. and Masters, C. J. (1967) The developmental multiplicity and isoenzyme status of cavian esterases. BBA - Enzymology, 132 2: 379-399. doi:10.1016/0005-2744(67)90157-X


Author Holmes, R. S.
Masters, C. J.
Title The developmental multiplicity and isoenzyme status of cavian esterases
Journal name BBA - Enzymology
ISSN 0005-2744
Publication date 1967-03-15
Sub-type Article (original research)
DOI 10.1016/0005-2744(67)90157-X
Open Access Status Not yet assessed
Volume 132
Issue 2
Start page 379
End page 399
Total pages 21
Language eng
Subject 2700 Medicine
Abstract 1. 1. With the aim of clarifying the isoenzyme status of esterases, the developmental and physicochemical properties of these enzymes have been studied in an extensive range of cavian tissues. 2. 2. A total of 24 multiple forms of esterolytic activity have been resolved, and the occurrence of these individual forms in the different tissues inter-related. 3. 3. By means of substrate and inhibitor studies, these heteromorphs have been characterized in four main classes: carboxylesterases, arylesterases, acetylesterases and cholinesterases. 4. 4. All of these classes are heterogeneous-the soluble carboxylesterases existing as 10 separate forms, arylesterases 4, cholinesterases 5, and acetylesterases 5. Each class multiplicity appears to be more extensive than has been previously reported. 5. 5. Further differentiation of the multiple forms in some of these major classes has been achieved on the basis of the physicochemical and developmental parameters utilized. This treatment would appear to implicate at least 12 structural genes in the biosynthesis of the soluble cavian esterases; a multiplicity of control which is, again, considerably in excess of previous estimations for mammalian sources. 6. 6. The significance of the localization and variation of individual esterases is discussed in relation to hormonal influences, cell metabolism and tissue individuality.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: Scopus Import
 
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Created: Fri, 29 Dec 2017, 00:17:30 EST