Linkage disequilibrium in domestic sheep

McRae, AF, McEwan, JC, Dodds, KG, Wilson, T, Crawford, AM and Slate, J (2002) Linkage disequilibrium in domestic sheep. Genetics, 160 3: 1113-1122.

Author McRae, AF
McEwan, JC
Dodds, KG
Wilson, T
Crawford, AM
Slate, J
Title Linkage disequilibrium in domestic sheep
Journal name Genetics   Check publisher's open access policy
ISSN 0016-6731
Publication date 2002-03-01
Year available 2002
Sub-type Article (original research)
Open Access Status Not yet assessed
Volume 160
Issue 3
Start page 1113
End page 1122
Total pages 10
Place of publication BALTIMORE
Publisher GENETICS
Language eng
Abstract The last decade has seen a dramatic increase in the number of livestock QTL mapping studies. The next challenge awaiting livestock geneticists is to determine the actual genes responsible for variation of economically important traits. With the advent of high density single nucleotide polymorphism (SNP) maps, it may be possible to fine map genes by exploiting linkage disequilibrium between genes of interest and adjacent markers. However, the extent of linkage disequilibrium (LD) is generally unknown for livestock populations. In this article microsatellite genotype data are used to assess the extent of LD in two populations of domestic sheep. High levels of LD were found to extend for tens of centimorgans and declined as a function of marker distance, However, LD was also frequently observed between unlinked markers. The prospects for LD mapping in livestock appear encouraging provided that type I error can be minimized. Properties of the multiallelic LD coefficient D' were also explored. D' was found to be significantly related to marker heterozygosity, although the relationship did not appear to unduly influence the overall conclusions. Of potentially greater concern was the observation that D' may be skewed when rare alleles are present. It is recommended that the statistical significance of LD is used in conjunction with coefficients such as D' to determine the trite extent of LD.
Keyword Quantitative Trait Loci
Common Disease Genes
Gametic Disequilibrium
Complex Disease
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collection: WoS Import
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Citation counts: TR Web of Science Citation Count  Cited 122 times in Thomson Reuters Web of Science Article | Citations
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Created: Mon, 25 Dec 2017, 21:43:26 EST