Bone density in sheep: genetic variation and quantitative trait loci localisation

Campbell, AW, Bain, WE, McRae, AF, Broad, TE, Johnstone, PD, Dodds, KG, Veenvliet, BA, Greer, GJ, Glass, BC, Beattie, AE, Jopson, NB and McEwan, JC (2003) Bone density in sheep: genetic variation and quantitative trait loci localisation. Bone, 33 4: 540-548. doi:10.1016/S8756-3282(03)00228-X


Author Campbell, AW
Bain, WE
McRae, AF
Broad, TE
Johnstone, PD
Dodds, KG
Veenvliet, BA
Greer, GJ
Glass, BC
Beattie, AE
Jopson, NB
McEwan, JC
Title Bone density in sheep: genetic variation and quantitative trait loci localisation
Journal name Bone   Check publisher's open access policy
ISSN 8756-3282
Publication date 2003-10-01
Year available 2003
Sub-type Article (original research)
DOI 10.1016/S8756-3282(03)00228-X
Open Access Status Not yet assessed
Volume 33
Issue 4
Start page 540
End page 548
Total pages 9
Place of publication NEW YORK
Publisher ELSEVIER SCIENCE INC
Language eng
Abstract Bone density (BD) is an important factor in osteoporotic fracture risk in humans. However, BD is a complex trait confounded by environmental influences and polygenic inheritance. Sheep provide a potentially useful model for studying differences in BD, as they provide a means of circumventing complex environmental factors and are a similar weight to humans. The aims of this study were to establish whether there is genetic variation in BD in sheep and then to localise quantitative trait loci (QTLs) associated with this variation. We also aimed to evaluate the relationship between fat and muscle body components and BD in sheep. Results showed that there was significant (P<0.01) genetic variation among Coopworth sheep sires for BD. This genetic difference was correlated (P<0.01) with body weight and muscle mass. A number of QTLs exceeding the suggestive threshold were identified (nine in total). Of these, two (chromosomes 1, P<0.05; chromosome 24, P<0.01) were significant using genome-wide permutation significance thresholds (2000 iterations). The position of the QTL on chromosome 24 coincided with a number of other body composition QTLs, indicating possible pleiotropic effects or the presence of multiple genes affecting body composition at that site. This study shows that sheep are potentially a useful model for studying the genetics of BD. (C) 2003 Elsevier Inc. All rights reserved.
Keyword D-Receptor Genotype
Mineral Density
Postmenopausal Women
Determining Linkage
Trabecular Bone
Marker Loci
Mass
Fracture
Qtl
Determinants
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collection: WoS Import
 
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Created: Mon, 25 Dec 2017, 21:24:15 EST