Examination of a region showing linkage map discrepancies across sheep breeds

McRae, AF and Beraldi, D (2006) Examination of a region showing linkage map discrepancies across sheep breeds. Mammalian Genome, 17 4: 346-353. doi:10.1007/s00335-005-0087-y


Author McRae, AF
Beraldi, D
Title Examination of a region showing linkage map discrepancies across sheep breeds
Journal name Mammalian Genome   Check publisher's open access policy
ISSN 0938-8990
Publication date 2006-04-01
Year available 2006
Sub-type Article (original research)
DOI 10.1007/s00335-005-0087-y
Open Access Status Not yet assessed
Volume 17
Issue 4
Start page 346
End page 353
Total pages 8
Place of publication NEW YORK
Publisher SPRINGER
Language eng
Abstract The availability of accurate linkage maps is an important step for the localization of genetic variants of interest. However, most studies in livestock assume the published map is applicable in their population despite the large differences between the breeds of a species. A region of sheep Chromosome 1 was previously identified as providing evidence for a marker order inconsistent with the published linkage map. In this study the identified region was investigated in more detail. Four microsatellite markers covering the central 5 cM of the inconsistent region and two flanking markers were genotyped in three sheep breeds, a commercial population (Charollais), an experimental population (Scottish Blackface), and a feral population (Soay). With the inclusion of the published linkage map, this provided evidence for three different marker orders across four sheep populations. Evidence for selection in this region was investigated using both a single-point allelic competition model and a multipoint allele-sharing statistic. Only the Charollais population provided evidence for selection, with significant transmission bias observed at marker BM7145. The implications of variation in linkage maps on the design and analysis of fine-mapping studies are discussed.
Keyword Recombination Rate
Bovine Genome
Translocation
Cattle
Sperm
Disequilibrium
Pig
Inversion
Interval
Humans
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collection: WoS Import
 
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Created: Mon, 25 Dec 2017, 20:36:20 EST