Cloning to reproduce desired genotypes

Westhusin, ME, Long, CR, Shin, T, Hill, , Looney, CR, Pryor, JH and Piedrahita, JA (2001). Cloning to reproduce desired genotypes. In: 27th Annual Conference of the International-Embryo-Transfer-Society, Omaha Nebraska, (35-49). Jan 13-16, 2001. doi:10.1016/S0093-691X(00)00444-1


Author Westhusin, ME
Long, CR
Shin, T
Hill,
Looney, CR
Pryor, JH
Piedrahita, JA
Title of paper Cloning to reproduce desired genotypes
Conference name 27th Annual Conference of the International-Embryo-Transfer-Society
Conference location Omaha Nebraska
Conference dates Jan 13-16, 2001
Journal name Theriogenology   Check publisher's open access policy
Place of Publication NEW YORK
Publisher ELSEVIER SCIENCE INC
Publication Year 2001
Year available 2001
Sub-type Fully published paper
DOI 10.1016/S0093-691X(00)00444-1
Open Access Status Not yet assessed
ISSN 0093-691X
Volume 55
Issue 1
Start page 35
End page 49
Total pages 15
Language eng
Abstract/Summary Cloned sheep, cattle, goats, pigs and mice have now been produced using somatic cells for nuclear transplantation. Animal cloning is still very inefficient with on average less than 10% of the cloned embryos transferred resulting in a live offspring. However successful cloning of a variety of different species and by a number of different laboratory groups has generated tremendous interest in reproducing desired genotypes. Some of these specific genotypes represent animal cell lines that have been genetically modified. In other cases there is a significant demand for cloning animals characterized by their inherent genetic value, for example prize livestock, household pets and rare or endangered species. A number of different variables may influence the ability to reproduce a specific genotype by cloning. These include species, source of recipient ova, cell type of nuclei donor, treatment of donor cells prior to nuclear transfer, and the techniques employed for nuclear transfer. At present, there is no solid evidence that suggests cloning will be limited to only a few specific animals, and in fact, most data collected to date suggests cloning will be applicable to a wide variety of different animals. The ability to reproduce any desired genotype by cloning will ultimately depend on the amount of time and resources invested in research. (C) 2000 by Elsevier Science inc.
Keyword Transplant Rabbit Embryos
Full-Term Development
In-Vitro Maturation
Inner Cell Mass
Nuclear Transfer
Fetal Fibroblasts
Enucleated Oocytes
Somatic-Cells
Mice
Adult
Q-Index Code E1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Conference Paper
Sub-type: Fully published paper
Collection: WoS Import
 
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Created: Sun, 24 Dec 2017, 16:26:33 EST