Comparing the reported burn conditions for different severity burns in porcine models: a systematic review

Andrews, Christine J. and Cuttle, Leila (2017) Comparing the reported burn conditions for different severity burns in porcine models: a systematic review. International Wound Journal, 14 6: 1199-1212. doi:10.1111/iwj.12786


Author Andrews, Christine J.
Cuttle, Leila
Title Comparing the reported burn conditions for different severity burns in porcine models: a systematic review
Journal name International Wound Journal   Check publisher's open access policy
ISSN 1742-4801
Publication date 2017-12-01
Year available 2017
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1111/iwj.12786
Open Access Status Not yet assessed
Volume 14
Issue 6
Start page 1199
End page 1212
Total pages 14
Place of publication HOBOKEN
Publisher WILEY
Language eng
Subject 2746 Surgery
2708 Dermatology
Abstract There are many porcine burn models that create burns using different materials (e.g. metal, water) and different burn conditions (e.g. temperature and duration of exposure). This review aims to determine whether a pooled analysis of these studies can provide insight into the burn materials and conditions required to create burns of a specific severity. A systematic review of 42 porcine burn studies describing the depth of burn injury with histological evaluation is presented. Inclusion criteria included thermal burns, burns created with a novel method or material, histological evaluation within 7 days post-burn and method for depth of injury assessment specified. Conditions causing deep dermal scald burns compared to contact burns of equivalent severity were disparate, with lower temperatures and shorter durations reported for scald burns (83 degrees C for 14 seconds) compared to contact burns (111 degrees C for 23 seconds). A valuable archive of the different mechanisms and materials used for porcine burn models is presented to aid design and optimisation of future models. Significantly, this review demonstrates the effect of the mechanism of injury on burn severity and that caution is recommended when burn conditions established by porcine contact burn models are used by regulators to guide scald burn prevention strategies.
Keyword Epidermal-Growth-Factor
Thickness Burn
Dermal Burns
Swine Model
Skin
Depth
Pig
Progression
Full
Regeneration
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collection: WoS Import
 
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Created: Sat, 23 Dec 2017, 23:54:28 EST