Nutrient partitioning during treatment of tuberculosis: gain in body fat mass but not in protein mass

Schwenk, Achim, Hodgson, Lisa, Wright, Antony, Ward, Leigh C., Rayner, Charlotte F. J., Grubnic, Sisa, Griffin, George E. and Macallan, Derek C. (2004) Nutrient partitioning during treatment of tuberculosis: gain in body fat mass but not in protein mass. American Journal of Clinical Nutrition, 79 6: 1006-1012.


Author Schwenk, Achim
Hodgson, Lisa
Wright, Antony
Ward, Leigh C.
Rayner, Charlotte F. J.
Grubnic, Sisa
Griffin, George E.
Macallan, Derek C.
Title Nutrient partitioning during treatment of tuberculosis: gain in body fat mass but not in protein mass
Journal name American Journal of Clinical Nutrition   Check publisher's open access policy
ISSN 0002-9165
Publication date 2004-06-01
Year available 2004
Sub-type Article (original research)
Open Access Status Not yet assessed
Volume 79
Issue 6
Start page 1006
End page 1012
Total pages 7
Place of publication Bethesda, MD
Publisher American Society for Nutrition
Language eng
Subject C1
321099 Clinical Sciences not elsewhere classified
730199 Clinical health not specific to particular organs, diseases and conditions
Abstract Background: Tuberculosis is an important cause of wasting. The functional consequences of wasting and recovery may depend on the distribution of lost and gained nutrient stores between protein and fat masses. Objective: The goal was to study nutrient partitioning, ie, the proportion of weight change attributable to changes in fat mass (FM) versus protein mass (PM), during anti mycobacterial treatment. Design: Body-composition measures were made of 21 men and 9 women with pulmonary tuberculosis at baseline and after 1 and 6 mo of treatment. All subjects underwent dual-energy X-ray absorptiometry and deuterium bromide dilution tests, and a four-compartment model of FM, total body water (TBW), bone minerals (BM), and PM was derived. The ratio of PM to FM at any time was expressed as the energy content (p-ratio). Changes in the p-ratio were related to disease severity as measured by radiologic criteria. Results: Patients gained 10% in body weight (P < 0.001) from baseline to month 6. This was mainly due to a 44% gain in FM (P < 0.001); PM, BM, and TBW did not change significantly. Results were similar in men and women. The p-ratio decreased from baseline to month 1 and then fell further by month 6. Radiologic disease severity was not correlated with changes in the p-ratio. Conclusions: Microbiological cure of tuberculosis does not restore PM within 6 mo, despite a strong anabolic response. Change in the p-ratio is a suitable parameter for use in studying the effect of disease on body composition because it allows transformation of such effects into a normal distribution across a wide range of baseline proportion between fat and protein mass.
Keyword Nutrition & Dietetics
Body Composition
Bromides
Densitometry
X-ray
Deuterium Oxide
Longitudinal Studies
Nutrient Partitioning
Nutritional Status
Tuberculosis
Wasting Syndrome
Pulmonary Tuberculosis
Energy-expenditure
4-component Model
Hiv-infection
Metabolism
Hydration
Depletion
Disease
Men
Q-Index Code C1
Institutional Status UQ

 
Versions
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 30 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 32 times in Scopus Article | Citations
Google Scholar Search Google Scholar
Created: Wed, 15 Aug 2007, 13:44:58 EST