Surges of increased T cell reactivity to an encephalitogenic region of myelin proteolipid protein occur more often in patients with multiple sclerosis than in healthy subjects

Pender, Michael P., Csurhes, Peter A., Greer, Judith M., Mowat, Paul D., Henderson, Robert D., Cameron, Kaye D., Purdie, David M., McCombe, Pamela A. and Good, Michael F. (2000) Surges of increased T cell reactivity to an encephalitogenic region of myelin proteolipid protein occur more often in patients with multiple sclerosis than in healthy subjects. Journal of Immunology, 165 9: 5322-5331. doi:10.4049/jimmunol.165.9.5322


Author Pender, Michael P.
Csurhes, Peter A.
Greer, Judith M.
Mowat, Paul D.
Henderson, Robert D.
Cameron, Kaye D.
Purdie, David M.
McCombe, Pamela A.
Good, Michael F.
Title Surges of increased T cell reactivity to an encephalitogenic region of myelin proteolipid protein occur more often in patients with multiple sclerosis than in healthy subjects
Journal name Journal of Immunology   Check publisher's open access policy
ISSN 0022-1767
Publication date 2000-11-01
Sub-type Article (original research)
DOI 10.4049/jimmunol.165.9.5322
Open Access Status Not yet assessed
Volume 165
Issue 9
Start page 5322
End page 5331
Total pages 10
Publisher American Association of Immunologists
Language eng
Subject 2403 Immunology
Abstract We have previously shown that patients with multiple sclerosis (MS) have increased T cell responses to the immunodominant region (residues 184-209) of myelin proteolipid protein (PLP). The present study investigated whether this reactivity fluctuates over time and correlates with disease activity. We performed monthly limiting dilution assays for 12-16 mo in four healthy subjects and live patients with relapsing-remitting MS to quantify the frequencies of circulating T cells proliferating in response to PLP, PLP, PLP, myelin basic protein (MBP) MBP, and tetanus toxoid. Disease activity was monitored by clinical assessment and gadolinium-enhanced magnetic resonance imaging of the brain. There were fluctuations in the frequencies of autoreactive T cells in all subjects. Compared with healthy controls, MS patients had significantly more frequent surges of T cells reactive to the 184-209 region of PLP, but infrequent surges of T cell reactivity to MBP. There was temporal clustering of the surges of T cell reactivity to MBP and MBP, suggesting T cell activation by environmental stimuli. Some clinical relapses were preceded by surges of T cell reactivity to PLP, and in one patient there was significant correlation between the frequency of T cells reactive to PLP and the total number of gadolinium-enhancing magnetic resonance imaging lesions. However, other relapses were not associated with surges of T cell reactivity to the Ags tested. T cells reactive to PLP may contribute to the development of some of the CNS lesions in MS.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: Scopus Import - Archived
 
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Created: Fri, 22 Dec 2017, 08:18:38 EST