The biosynthesis of sesquiterpene isocyanides and isothiocyanates in the marine sponge Acanthella cavernosa (Dendy); evidence for dietary transfer to the dorid nudibranch Phyllidiella pustulosa

Dumdei, Eric J., Flowers, Andrew E., Garson, Mary J. and Moore, Christopher J. (1997) The biosynthesis of sesquiterpene isocyanides and isothiocyanates in the marine sponge Acanthella cavernosa (Dendy); evidence for dietary transfer to the dorid nudibranch Phyllidiella pustulosa. Comparative Biochemistry and Physiology - A Physiology, 118 4: 1385-1392. doi:10.1016/S0300-9629(97)00051-0


Author Dumdei, Eric J.
Flowers, Andrew E.
Garson, Mary J.
Moore, Christopher J.
Title The biosynthesis of sesquiterpene isocyanides and isothiocyanates in the marine sponge Acanthella cavernosa (Dendy); evidence for dietary transfer to the dorid nudibranch Phyllidiella pustulosa
Journal name Comparative Biochemistry and Physiology - A Physiology   Check publisher's open access policy
ISSN 0300-9629
Publication date 1997-12-01
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1016/S0300-9629(97)00051-0
Open Access Status Not yet assessed
Volume 118
Issue 4
Start page 1385
End page 1392
Total pages 8
Language eng
Subject 1314 Physiology
Abstract The tropical marine sponge Acanthella cavernosa (Dendy) converts potassium [C] cyanide to axisonitrile-3 (1); this precursor is also used for the synthesis of axisothiocyanate-3 (2) suggesting that isocyanides are precursors to isothiocyanates in A. cavernosa. Likewise, potassium [C] thiocyanate is used for the synthesis of axisothiocyanate-3; unexpectedly this precursor also labelled axisonitrile-3. These results demonstrate either an interconversion between cyanide and thiocyanate prior to secondary metabolite formation or that the secondary metabolites can themselves be interconverted. Specimens of the dorid nudibranch Phyllidiella pustulosa, preadapted to a diet of A. cavernosa, fed on C-labelled sponges and were subsequently found to contain the radioactive terpenes (1) and (2). Specimens of P. pustulosa, which had not expressed a dietary preference for A. cavernosa in the field, did not generally feed in aquarium tests with C- labelled sponges and, therefore, provided non-radioactive extracts. Since control experiments demonstrated the inability of P. pustulosa to synthesise the metabolites de novo, we therefore conclude that P. pustulosa acquires secondary metabolites by dietary transfer from A. cavernosa.
Keyword Acanthella cavernosa (Dendy)
Biosynthesis
Isocyanides
Isothiocyanates
Metabolite transfer
Nudibranch
Phyllidiella pustulosa
Sponge
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collection: Scopus Import - Archived
 
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Created: Fri, 22 Dec 2017, 06:08:31 EST