Changes in body composition and muscle protein degradation during nutritional supplementation in nutritionally growth-retarded children with cystic fibrosis

Shepherd, R. W., Thomas, B. J., Bennett, D., Cooksley, W. and Ward, L. C. (1983) Changes in body composition and muscle protein degradation during nutritional supplementation in nutritionally growth-retarded children with cystic fibrosis. Journal of Pediatric Gastroenterology and Nutrition, 2 3: 439-446.

Author Shepherd, R. W.
Thomas, B. J.
Bennett, D.
Cooksley, W.
Ward, L. C.
Title Changes in body composition and muscle protein degradation during nutritional supplementation in nutritionally growth-retarded children with cystic fibrosis
Journal name Journal of Pediatric Gastroenterology and Nutrition   Check publisher's open access policy
ISSN 1536-4801
0277-2116
Publication date 1983-01-01
Sub-type Article (original research)
Open Access Status Not yet assessed
Volume 2
Issue 3
Start page 439
End page 446
Total pages 8
Language eng
Subject 2735 Pediatrics, Perinatology, and Child Health
2715 Gastroenterology
Abstract Changes in body composition and muscle protein degradation were studied in seven nutritionally growth-retarded children with cystic fibrosis (CF) before and after nutritional supplementation and in eight healthy children who served as controls. Supplemental feedings consisted of a peptide formula that increased dietary protein and energy intakes approximately 20-40% over a 6-month period, delivered either as oral supplement or overnight intragastric feeding. Body composition was assessed by anthropometric data and measurements of whole body potassium (40K) and creatinine excretion. Muscle protein degradation was measured by urinary 3-methyl-histidine excretion, an index of myofibrillar protein catabolism. Compared with controls, CF children had significantly reduced body mass, body fat, and muscle mass, and a significantly increased rate of myofibrillar protein degradation. With nutritional supplementation, signifi-cant catch-up weight gain and improved linear growth were observed with evidence of accretion of lean body mass and muscle mass, and in all but one severely malnourished patient with progressive disease, there was normalization of the high rate of muscle protein degradation. Thus, this form of nutritional therapy has significant benefits in terms of body protein accretion and myofibrillar protein degradation.
Keyword Cystic fibrosis
Growth retardation
Nutritional supplementation
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: Scopus Import
 
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Created: Fri, 22 Dec 2017, 01:57:33 EST