HBV core sequence: definition of genotype-specific variability and correlation with geographical origin

Jazayeri, M., Basuni, A. A., Sran, N., Gish, R., Cooksley, G., Locarnini, S. and Carman, W. F. (2004) HBV core sequence: definition of genotype-specific variability and correlation with geographical origin. Journal of Viral Hepatitis, 11 6: 488-501. doi:10.1111/j.1365-2893.2004.00534.x


Author Jazayeri, M.
Basuni, A. A.
Sran, N.
Gish, R.
Cooksley, G.
Locarnini, S.
Carman, W. F.
Title HBV core sequence: definition of genotype-specific variability and correlation with geographical origin
Journal name Journal of Viral Hepatitis   Check publisher's open access policy
ISSN 1352-0504
Publication date 2004-01-01
Sub-type Article (original research)
DOI 10.1111/j.1365-2893.2004.00534.x
Volume 11
Issue 6
Start page 488
End page 501
Total pages 14
Editor H. C. Thomas
Place of publication Oxford, U.K.
Publisher Blackwell Publishing
Language eng
Subject C1
321010 Infectious Diseases
730101 Infectious diseases
Abstract There are eight genotypes and nine subtypes of HBV. Small differences in geographical origin are associated with sequence changes in the surface gene. Here, we compared core gene sequences from different genotypes and geographical regions. Specific combinations of 24 amino acid substitutions at nine residues allowed allocation of a sequence to a subtype. Six of these nine residues were located in different T cell epitopes depending on HBV geographical area and/or genotype. Thirty-seven nucleotide changes were associated uniquely with specific genotypes and subtypes. Unique amino acid and nucleotide variants were found in a majority of sequences from specific countries as well as within subtype ayw2 and adr. Specific nucleotide motifs were defined for Korean, Indian, Chinese, Italian and Pacific region isolates. Finally, we observed amino acid motifs that were common to either South-east Asian or Western populations, irrespective of subtype. We believe that HBV strains spread within constrained ethnic groups, result in selection pressures that define sequence variability within each subtype. It suggests that particular T cell epitopes are specific for geographical regions, and thus ethnic groups; this may affect the design of immunomodulatory therapies.
Keyword Gastroenterology & Hepatology
Infectious Diseases
Virology
C Gene Variability
Hbcag
Hbv Genotypes
Hbv Subtypes
Hepatitis-b-virus
Complete Nucleotide-sequences
Naturally-occurring Mutation
Surface-antigen Subtypes
Chronic Active Hepatitis
T-cell Epitopes
Fulminant-hepatitis
Phylogenetic Relatedness
Nucleocapsid Antigen
Immature Secretion
Q-Index Code C1

Document type: Journal Article
Sub-type: Article (original research)
Collections: Excellence in Research Australia (ERA) - Collection
2005 Higher Education Research Data Collection
School of Medicine Publications
 
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Created: Wed, 15 Aug 2007, 13:40:14 EST