In life there is death: How epithelial tissue barriers are preserved despite the challenge of apoptosis

Duszyc, Kinga, Gomez, Guillermo A., Schroder, Kate, Sweet, Matthew J. and Yap, Alpha S. (2017) In life there is death: How epithelial tissue barriers are preserved despite the challenge of apoptosis. Tissue Barriers, 5 4: e1345353. doi:10.1080/21688370.2017.1345353


Author Duszyc, Kinga
Gomez, Guillermo A.
Schroder, Kate
Sweet, Matthew J.
Yap, Alpha S.
Title In life there is death: How epithelial tissue barriers are preserved despite the challenge of apoptosis
Journal name Tissue Barriers
ISSN 2168-8370
2168-8362
Publication date 2017-07-07
Year available 2017
Sub-type Article (original research)
DOI 10.1080/21688370.2017.1345353
Open Access Status Not yet assessed
Volume 5
Issue 4
Start page e1345353
Total pages 12
Place of publication Philadelphia, PA United States
Publisher Taylor and Francis
Language eng
Subject 1303 Biochemistry
2722 Histology
1307 Cell Biology
Abstract Apoptosis is a ubiquitous mode of programmed cell death that is found in healthy organs and can be stimulated by many toxic stresses. When it occurs in epithelia, apoptosis presents major challenges to tissue integrity. Apoptotic corpses can promote inflammatory and autoimmune responses if they are retained, and the cellular fragmentation that accompanies apoptosis can potentially compromise the epithelial barrier. Here we discuss 2 homeostatic mechanisms that allow epithelia to circumvent these potential risks: clearance of apoptotic corpses by professional and non-professional phagocytes and physical expulsion of apoptotic cells by apical extrusion. Extrusion and phagocytosis may represent complementary responses that preserve epithelial integrity despite the inevitable challenge of apoptosis.
Keyword apoptosis
epithelia
extrusion
phagocytosis
tissue mechanics
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: HERDC Pre-Audit
School of Biomedical Sciences Publications
Institute for Molecular Bioscience - Publications
 
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Created: Sat, 16 Dec 2017, 21:52:32 EST