Oxidative toxicity in diabetes and Alzheimer's disease: Mechanisms behind ROS/ RNS generation

Ahmad, Waqar, Ijaz, Bushra, Shabbiri, Khadija, Ahmed, Fayyaz and Rehman, Sidra (2017) Oxidative toxicity in diabetes and Alzheimer's disease: Mechanisms behind ROS/ RNS generation. Journal of Biomedical Science, 24 1: 1-10. doi:10.1186/s12929-017-0379-z


Author Ahmad, Waqar
Ijaz, Bushra
Shabbiri, Khadija
Ahmed, Fayyaz
Rehman, Sidra
Title Oxidative toxicity in diabetes and Alzheimer's disease: Mechanisms behind ROS/ RNS generation
Journal name Journal of Biomedical Science   Check publisher's open access policy
ISSN 1423-0127
1021-7770
Publication date 2017-09-19
Year available 2017
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1186/s12929-017-0379-z
Open Access Status DOI
Volume 24
Issue 1
Start page 1
End page 10
Total pages 10
Place of publication London, United Kingdom
Publisher BioMed Central
Language eng
Subject 2712 Endocrinology, Diabetes and Metabolism
1312 Molecular Biology
1308 Clinical Biochemistry
1307 Cell Biology
2704 Biochemistry, medical
2736 Pharmacology (medical)
Abstract Reactive oxidative species (ROS) toxicity remains an undisputed cause and link between Alzheimer's disease (AD) and Type-2 Diabetes Mellitus (T2DM). Patients with both AD and T2DM have damaged, oxidized DNA, RNA, protein and lipid products that can be used as possible disease progression markers. Although the oxidative stress has been anticipated as a main cause in promoting both AD and T2DM, multiple pathways could be involved in ROS production. The focus of this review is to summarize the mechanisms involved in ROS production and their possible association with AD and T2DM pathogenesis and progression. We have also highlighted the role of current treatments that can be linked with reduced oxidative stress and damage in AD and T2DM.
Keyword Alzheimer's disease
Anti-diabetic drugs
Antioxidant treatments
Oxidative stress
ROS production
Type-2 diabetes mellitus
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: HERDC Pre-Audit
School of Biological Sciences Publications
 
Versions
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 1 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 2 times in Scopus Article | Citations
Google Scholar Search Google Scholar
Created: Sat, 16 Dec 2017, 21:03:51 EST