Sex Determination in the Mammalian Germline

Spiller, Cassy, Koopman, Peter and Bowles, Josephine (2017) Sex Determination in the Mammalian Germline. Annual Review of Genetics, 51 265-285. doi:10.1146/annurev-genet-120215-035449

Author Spiller, Cassy
Koopman, Peter
Bowles, Josephine
Title Sex Determination in the Mammalian Germline
Journal name Annual Review of Genetics   Check publisher's open access policy
ISSN 1545-2948
ISBN 978-0-8243-1251-0
Publication date 2017-08-30
Year available 2017
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1146/annurev-genet-120215-035449
Open Access Status Not yet assessed
Volume 51
Start page 265
End page 285
Total pages 21
Editor Bonini, NM
Place of publication Palo Alto, CA United States
Publisher Annual Reviews
Language eng
Subject 1311 Genetics
Abstract Sexual reproduction crucially depends on the production of sperm in males and oocytes in females. Both types of gamete arise from the same precursor, the germ cells. We review the events that characterize the development of germ cells during fetal life as they commit to, and prepare for, oogenesis or spermatogenesis. In females, fetal germ cells enter meiosis, whereas in males they delay meiosis and instead lose pluripotency, activate an irreversible program of prospermatogonial differentiation, and temporarily cease dividing. Both pathways involve sex-specific molecular signals from the somatic cells of the developing gonads and a suite of intrinsic receptors, signal transducers, transcription factors, RNA stability factors, and epigenetic modulators that act in complex, interconnected positive and negative regulatory networks. Understanding these networks is important in the contexts of the etiology, diagnosis, and treatment of infertility and gonadal cancers, and in efforts to augment human and animal fertility using stem cell approaches.
Keyword Germ cell
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: HERDC Pre-Audit
School of Biomedical Sciences Publications
Institute for Molecular Bioscience - Publications
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Citation counts: TR Web of Science Citation Count  Cited 1 times in Thomson Reuters Web of Science Article | Citations
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Created: Sat, 16 Dec 2017, 20:11:57 EST