Therapeutic activation of V alpha 24(+)V beta 11(+) NKT cells in human subjects results in highly coordinated secondary activation of acquired and innate immunity

Nieda, M, Okai, M, Tazbirkova, A, Lin, H, Yamaura, A, Ide, K, Abraham, R, Juji, T, Macfarlane, DJ and Nicol, AJ (2004) Therapeutic activation of V alpha 24(+)V beta 11(+) NKT cells in human subjects results in highly coordinated secondary activation of acquired and innate immunity. Blood, 103 2: 383-389. doi:10.1182/blood-2003-04-1155


Author Nieda, M
Okai, M
Tazbirkova, A
Lin, H
Yamaura, A
Ide, K
Abraham, R
Juji, T
Macfarlane, DJ
Nicol, AJ
Title Therapeutic activation of V alpha 24(+)V beta 11(+) NKT cells in human subjects results in highly coordinated secondary activation of acquired and innate immunity
Journal name Blood   Check publisher's open access policy
ISSN 0006-4971
Publication date 2004-01-01
Sub-type Article (original research)
DOI 10.1182/blood-2003-04-1155
Volume 103
Issue 2
Start page 383
End page 389
Total pages 7
Editor S. J. Shathi
Place of publication Washington, U.S.A.
Publisher American Society of Hematology
Language eng
Subject C1
320205 Transplantation Immunology
730102 Immune system and allergy
Abstract Human Valpha24(+)Vbeta11(+) natural killer T (NKT) cells are a distinct CD1d-restricted lymphoid subset specifically and potently activated by alpha-galactosylceramide (alpha-GalCer) (KRN7000) presented by CD1 d on antigen-presenting cells. Preclinical models show that activation of Valpha24(+)Vbeta11(+) NKT cells induces effective antitumor immune responses and potentially important secondary immune effects, including activation of conventional T cells and NK cells. We describe the first clinical trial of cancer immune therapy with alpha-GalCer-pulsed CD1d-expressing dendritic cells. The results show that this therapy has substantial, rapid, and highly reproducible specific effects on Valpha24(+)Vbeta11(+) NKT cells and provide the first human in vivo evidence that Valpha24(+)Vbeta11(+) NKT cell stimulation leads to activation of both innate and acquired immunity, resulting in modulation of NK, T-, and B-cell numbers and increased serum interferon-gamma. We present the first clinical evidence that Valpha24(+)Vbeta11(+) NKT cell memory produces faster, more vigorous secondary immune responses by innate and acquired immunity upon restimulation.
Keyword Hematology
Killer T-cells
Pulsed Dendritic Cells
Alpha-galactosylceramide
Salmonella Infection
Glycolipid Antigens
Cutting Edge
Ifn-gamma
In-vitro
Liver
Mice
Q-Index Code C1

Document type: Journal Article
Sub-type: Article (original research)
Collections: Excellence in Research Australia (ERA) - Collection
2005 Higher Education Research Data Collection
School of Medicine Publications
 
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Created: Wed, 15 Aug 2007, 13:35:09 EST