Diffusion modeling of percutaneous absorption kinetics: 3. Variable diffusion and partition coefficients, consequences for stratum corneum depth profiles and desorption kinetics

Anissimov, YG and Roberts, MS (2004) Diffusion modeling of percutaneous absorption kinetics: 3. Variable diffusion and partition coefficients, consequences for stratum corneum depth profiles and desorption kinetics. Journal of Pharmaceutical Sciences, 93 2: 470-487. doi:10.1002/jps.10567


Author Anissimov, YG
Roberts, MS
Title Diffusion modeling of percutaneous absorption kinetics: 3. Variable diffusion and partition coefficients, consequences for stratum corneum depth profiles and desorption kinetics
Journal name Journal of Pharmaceutical Sciences   Check publisher's open access policy
ISSN 0022-3549
Publication date 2004-01-01
Year available 2004
Sub-type Article (original research)
DOI 10.1002/jps.10567
Open Access Status
Volume 93
Issue 2
Start page 470
End page 487
Total pages 18
Editor R. T. Borchardt
Place of publication USA
Publisher John Wiley & Sons, Inc
Language eng
Subject C1
320501 Pharmaceutical Sciences and Pharmacy
730118 Organs, diseases and abnormal conditions not elsewhere classified
Abstract Stratum corneum (SC) desorption experiments have yielded higher calculated steady-state fluxes than those obtained by epidermal penetration studies. A possible explanation of this result is a variable diffusion or partition coefficient across the SC. We therefore developed the diffusion model for percutaneous penetration and desorption to study the effects of either a variable diffusion coefficient or variable partition coefficient in the SC over the diffusion path length. Steady-state flux, lag time, and mean desorption time were obtained from Laplace domain solutions. Numerical inversion of the Laplace domain solutions was used for simulations of solute concentration-distance and amount penetrated (desorbed)-time profiles. Diffusion and partition coefficients heterogeneity were examined using six different models. The effect of heterogeneity on predicted flux from desorption studies was compared with that obtained in permeation studies. Partition coefficient heterogeneity had a more profound effect on predicted fluxes than diffusion coefficient heterogeneity. Concentration-distance profiles show even larger dependence on heterogeneity, which is consistent with experimental tape-stripping data reported for clobetasol propionate and other solutes. The clobetasol propionate tape-stripping data were most consistent with the partition coefficient decreasing exponentially for half the SC and then becoming a constant for the remaining SC. (C) 2004 Wiley-Liss, Inc.
Keyword Chemistry, Multidisciplinary
Pharmacology & Pharmacy
Diffusion
Mathematical Models
Transdermal
Permeability
Heterogeneity
In-vivo
Barrier
Transport
Membranes
Water
Skin
Chemistry, Medicinal
Q-Index Code C1
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Excellence in Research Australia (ERA) - Collection
2005 Higher Education Research Data Collection
School of Medicine Publications
 
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Citation counts: TR Web of Science Citation Count  Cited 34 times in Thomson Reuters Web of Science Article | Citations
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Created: Wed, 15 Aug 2007, 13:29:38 EST