Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression

Wray, Naomi R, Ripke, Stephan, Mattheisen, Manuel, Trzaskowski, Maciej, Byrne, Enda M, Abdellaoui, Abdel, Adams, Mark J, Agerbo, Esben, Air, Tracy M, Andlauer, Till M F, Bacanu, Silviu-Alin, Bækvad-Hansen, Marie, Beekman, Aartjan F T, Bigdeli, Tim B, Binder, Elisabeth B, Blackwood, Douglas R H, Bryois, Julien, Buttenschøn, Henriette N, Bybjerg-Grauholm, Jonas, Cai, Na, Castelao, Enrique, Christensen, Jane Hvarregaard, Clarke, Toni-Kim, Coleman, Jonathan I R, Colodro-Conde, Lucía, Couvy-Duchesne, Baptiste, Craddock, Nick, Crawford, Gregory E, Crowley, Cheynna A, Dashti, Hassan S, Davies, Gail, Deary, Ian J, Degenhardt, Franziska, Derks, Eske M, Direk, Nese, Dolan, Conor V, Dunn, Erin C, Eley, Thalia C, Eriksson, Nicholas, Escott-Price, Valentina, Kiadeh, Farnush Hassan Farhadi, Finucane, Hilary K, Forstner, Andreas J, Frank, Josef, Gaspar, Héléna A, Gill, Michael, Giusti-Rodríguez, Paola, Goes, Fernando S, Gordon, Scott D, Grove, Jakob, Hall, Lynsey S, Hannon, Eilis, Hansen, Christine Søholm, Hansen, Thomas F, Herms, Stefan, Hickie, Ian B, Hoffmann, Per, Homuth, Georg, Horn, Carsten, Hottenga, Jouke-Jan, Hougaard, David M, Hu, Ming, Hyde, Craig L, Ising, Marcus, Jansen, Rick, Jin, Fulai, Jorgenson, Eric, Knowles, James A, Kohane, Isaac S, Kraft, Julia, Kretzschmar, Warren W, Krogh, Jesper, Kutalik, Zoltán, Lane, Jacqueline M, Li, Yihan, Li, Yun, Lind, Penelope A, Liu, Xiaoxiao, Lu, Leina, MacIntyre, Donald J, MacKinnon, Dean F, Maier, Robert M, Maier, Wolfgang, Marchini, Jonathan, Mbarek, Hamdi, McGrath, Patrick, McGuffin, Peter, Medland, Sarah E, Mehta, Divya, Middeldorp, Christel M, Mihailov, Evelin, Milaneschi, Yuri, Milani, Lili, Mill, Jonathan, Mondimore, Francis M, Montgomery, Grant W, Mostafavi, Sara, Mullins, Niamh, Nauck, Matthias, Ng, Bernard, Nivard, Michel G, Nyholt, Dale R, O'Reilly, Paul F, Oskarsson, Hogni, Owen, Michael J, Painter, Jodie N, Pedersen, Carsten Bøcker, Pedersen, Marianne Giørtz, Peterson, Roseann E, Pettersson, Erik, Peyrot, Wouter J, Pistis, Giorgio, Posthuma, Danielle, Purcell, Shaun M, Quiroz, Jorge A, Qvist, Per, Rice, John P, Riley, Brien P, Rivera, Margarita, Saeed Mirza, Saira, Saxena, Richa, Schoevers, Robert, Schulte, Eva C, Shen, Ling, Shi, Jianxin, Shyn, Stanley I, Sigurdsson, Engilbert, Sinnamon, Grant B C, Smit, Johannes H, Smith, Daniel J, Stefansson, Hreinn, Steinberg, Stacy, Stockmeier, Craig A, Streit, Fabian, Strohmaier, Jana, Tansey, Katherine E, Teismann, Henning, Teumer, Alexander, Thompson, Wesley, Thomson, Pippa A, Thorgeirsson, Thorgeir E, Tian, Chao, Traylor, Matthew, Treutlein, Jens, Trubetskoy, Vassily, Uitterlinden, André G, Umbricht, Daniel, Van der Auwera, Sandra, van Hemert, Albert M, Viktorin, Alexander, Visscher, Peter M, Wang, Yunpeng, Webb, Bradley T, Weinsheimer, Shantel Marie, Wellmann, Jürgen, Willemsen, Gonneke, Witt, Stephanie H, Wu, Yang, Xi, Hualin S, Yang, Jian, Zhang, Futao, eQTLGen, 23andMe, Arolt, Volker, Baune, Bernhard T, Berger, Klaus, Boomsma, Dorret I, Cichon, Sven, Dannlowski, Udo, de Geus, E C J, DePaulo, J Raymond, Domenici, Enrico, Domschke, Katharina, Esko, Tõnu, Grabe, Hans J, Hamilton, Steven P, Hayward, Caroline, Heath, Andrew C, Hinds, David A, Kendler, Kenneth S, Kloiber, Stefan, Lewis, Glyn, Li, Qingqin S, Lucae, Susanne, Madden, Pamela F A, Magnusson, Patrik K, Martin, Nicholas G, McIntosh, Andrew M, Metspalu, Andres, Mors, Ole, Mortensen, Preben Bo, Müller-Myhsok, Bertram, Nordentoft, Merete, Nöthen, Markus M, O'Donovan, Michael C, Paciga, Sara A, Pedersen, Nancy L, Penninx, Brenda W J H, Perlis, Roy H, Porteous, David J, Potash, James B, Preisig, Martin, Rietschel, Marcella, Schaefer, Catherine, Schulze, Thomas G, Smoller, Jordan W, Stefansson, Kari, Tiemeier, Henning, Uher, Rudolf, Völzke, Henry, Weissman, Myrna M, Werge, Thomas, Winslow, Ashley R, Lewis, Cathryn M, Levinson, Douglas F, Breen, Gerome, Børglum, Anders D, Sullivan, Patrick F and Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium (2018) Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression. Nature genetics, 50 5: 668-681. doi:10.1038/s41588-018-0090-3


Author Wray, Naomi R
Ripke, Stephan
Mattheisen, Manuel
Trzaskowski, Maciej
Byrne, Enda M
Abdellaoui, Abdel
Adams, Mark J
Agerbo, Esben
Air, Tracy M
Andlauer, Till M F
Bacanu, Silviu-Alin
Bækvad-Hansen, Marie
Beekman, Aartjan F T
Bigdeli, Tim B
Binder, Elisabeth B
Blackwood, Douglas R H
Bryois, Julien
Buttenschøn, Henriette N
Bybjerg-Grauholm, Jonas
Cai, Na
Castelao, Enrique
Christensen, Jane Hvarregaard
Clarke, Toni-Kim
Coleman, Jonathan I R
Colodro-Conde, Lucía
Couvy-Duchesne, Baptiste
Craddock, Nick
Crawford, Gregory E
Crowley, Cheynna A
Dashti, Hassan S
Davies, Gail
Deary, Ian J
Degenhardt, Franziska
Derks, Eske M
Direk, Nese
Dolan, Conor V
Dunn, Erin C
Eley, Thalia C
Eriksson, Nicholas
Escott-Price, Valentina
Kiadeh, Farnush Hassan Farhadi
Finucane, Hilary K
Forstner, Andreas J
Frank, Josef
Gaspar, Héléna A
Gill, Michael
Giusti-Rodríguez, Paola
Goes, Fernando S
Gordon, Scott D
Grove, Jakob
Hall, Lynsey S
Hannon, Eilis
Hansen, Christine Søholm
Hansen, Thomas F
Herms, Stefan
Hickie, Ian B
Hoffmann, Per
Homuth, Georg
Horn, Carsten
Hottenga, Jouke-Jan
Hougaard, David M
Hu, Ming
Hyde, Craig L
Ising, Marcus
Jansen, Rick
Jin, Fulai
Jorgenson, Eric
Knowles, James A
Kohane, Isaac S
Kraft, Julia
Kretzschmar, Warren W
Krogh, Jesper
Kutalik, Zoltán
Lane, Jacqueline M
Li, Yihan
Li, Yun
Lind, Penelope A
Liu, Xiaoxiao
Lu, Leina
MacIntyre, Donald J
MacKinnon, Dean F
Maier, Robert M
Maier, Wolfgang
Marchini, Jonathan
Mbarek, Hamdi
McGrath, Patrick
McGuffin, Peter
Medland, Sarah E
Mehta, Divya
Middeldorp, Christel M
Mihailov, Evelin
Milaneschi, Yuri
Milani, Lili
Mill, Jonathan
Mondimore, Francis M
Montgomery, Grant W
Mostafavi, Sara
Mullins, Niamh
Nauck, Matthias
Ng, Bernard
Nivard, Michel G
Nyholt, Dale R
O'Reilly, Paul F
Oskarsson, Hogni
Owen, Michael J
Painter, Jodie N
Pedersen, Carsten Bøcker
Pedersen, Marianne Giørtz
Peterson, Roseann E
Pettersson, Erik
Peyrot, Wouter J
Pistis, Giorgio
Posthuma, Danielle
Purcell, Shaun M
Quiroz, Jorge A
Qvist, Per
Rice, John P
Riley, Brien P
Rivera, Margarita
Saeed Mirza, Saira
Saxena, Richa
Schoevers, Robert
Schulte, Eva C
Shen, Ling
Shi, Jianxin
Shyn, Stanley I
Sigurdsson, Engilbert
Sinnamon, Grant B C
Smit, Johannes H
Smith, Daniel J
Stefansson, Hreinn
Steinberg, Stacy
Stockmeier, Craig A
Streit, Fabian
Strohmaier, Jana
Tansey, Katherine E
Teismann, Henning
Teumer, Alexander
Thompson, Wesley
Thomson, Pippa A
Thorgeirsson, Thorgeir E
Tian, Chao
Traylor, Matthew
Treutlein, Jens
Trubetskoy, Vassily
Uitterlinden, André G
Umbricht, Daniel
Van der Auwera, Sandra
van Hemert, Albert M
Viktorin, Alexander
Visscher, Peter M
Wang, Yunpeng
Webb, Bradley T
Weinsheimer, Shantel Marie
Wellmann, Jürgen
Willemsen, Gonneke
Witt, Stephanie H
Wu, Yang
Xi, Hualin S
Yang, Jian
Zhang, Futao
eQTLGen
23andMe
Arolt, Volker
Baune, Bernhard T
Berger, Klaus
Boomsma, Dorret I
Cichon, Sven
Dannlowski, Udo
de Geus, E C J
DePaulo, J Raymond
Domenici, Enrico
Domschke, Katharina
Esko, Tõnu
Grabe, Hans J
Hamilton, Steven P
Hayward, Caroline
Heath, Andrew C
Hinds, David A
Kendler, Kenneth S
Kloiber, Stefan
Lewis, Glyn
Li, Qingqin S
Lucae, Susanne
Madden, Pamela F A
Magnusson, Patrik K
Martin, Nicholas G
McIntosh, Andrew M
Metspalu, Andres
Mors, Ole
Mortensen, Preben Bo
Müller-Myhsok, Bertram
Nordentoft, Merete
Nöthen, Markus M
O'Donovan, Michael C
Paciga, Sara A
Pedersen, Nancy L
Penninx, Brenda W J H
Perlis, Roy H
Porteous, David J
Potash, James B
Preisig, Martin
Rietschel, Marcella
Schaefer, Catherine
Schulze, Thomas G
Smoller, Jordan W
Stefansson, Kari
Tiemeier, Henning
Uher, Rudolf
Völzke, Henry
Weissman, Myrna M
Werge, Thomas
Winslow, Ashley R
Lewis, Cathryn M
Levinson, Douglas F
Breen, Gerome
Børglum, Anders D
Sullivan, Patrick F
Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium
Title Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression
Journal name Nature genetics   Check publisher's open access policy
ISSN 1546-1718
Publication date 2018-04-26
Sub-type Article (original research)
DOI 10.1038/s41588-018-0090-3
Open Access Status PMC
Volume 50
Issue 5
Start page 668
End page 681
Total pages 14
Publisher Nature Publishing Group
Language eng
Subject 1311 Genetics
Abstract Major depressive disorder (MDD) is a common illness accompanied by considerable morbidity, mortality, costs, and heightened risk of suicide. We conducted a genome-wide association meta-analysis based in 135,458 cases and 344,901 controls and identified 44 independent and significant loci. The genetic findings were associated with clinical features of major depression and implicated brain regions exhibiting anatomical differences in cases. Targets of antidepressant medications and genes involved in gene splicing were enriched for smaller association signal. We found important relationships of genetic risk for major depression with educational attainment, body mass, and schizophrenia: lower educational attainment and higher body mass were putatively causal, whereas major depression and schizophrenia reflected a partly shared biological etiology. All humans carry lesser or greater numbers of genetic risk factors for major depression. These findings help refine the basis of major depression and imply that a continuous measure of risk underlies the clinical phenotype.
Q-Index Code C1
Q-Index Status Provisional Code
Grant ID U01 MH085520
U01 MH094421
U01 MH109528
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: Pubmed Import
 
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Created: Wed, 02 May 2018, 10:04:50 EST