IL-6 promotes CD4(+) T-cell and B-cell activation during Plasmodium infection

Sebina, I., Fogg, L. G., James, K. R., Soon, M. S. F., Akter, J., Thomas, B. S., Hill, G. R., Engwerda, C. R. and Haque, A. (2017) IL-6 promotes CD4(+) T-cell and B-cell activation during Plasmodium infection. Parasite Immunology, 39 10: 1-10. doi:10.1111/pim.12455

Author Sebina, I.
Fogg, L. G.
James, K. R.
Soon, M. S. F.
Akter, J.
Thomas, B. S.
Hill, G. R.
Engwerda, C. R.
Haque, A.
Title IL-6 promotes CD4(+) T-cell and B-cell activation during Plasmodium infection
Journal name Parasite Immunology   Check publisher's open access policy
ISSN 0141-9838
Publication date 2017-08-17
Year available 2017
Sub-type Article (original research)
DOI 10.1111/pim.12455
Open Access Status Not yet assessed
Volume 39
Issue 10
Start page 1
End page 10
Total pages 10
Place of publication Chichester, West Sussex United Kingdom
Publisher Wiley-Blackwell Publishing
Language eng
Subject 2405 Parasitology
2403 Immunology
Abstract Humoral immunity develops in the spleen during blood-stage Plasmodium infection. This elicits parasite-specific IgM and IgG, which control parasites and protect against malaria. Studies in mice have elucidated cells and molecules driving humoral immunity to Plasmodium, including CD4(+) T cells, B cells, interleukin (IL)-21 and ICOS. IL-6, a cytokine readily detected in Plasmodium-infected mice and humans, is recognized in other systems as a driver of humoral immunity. Here, we examined the effect of infection-induced IL-6 on humoral immunity to Plasmodium. Using P.chabaudi chabaudi AS (PcAS) infection of wild-type and IL-6(-/-) mice, we found that IL-6 helped to control parasites during primary infection. IL-6 promoted early production of parasite-specific IgM but not IgG. Notably, splenic CD138(+) plasmablast development was more dependent on IL-6 than germinal centre (GC) B-cell differentiation. IL-6 also promoted ICOS expression by CD4(+) T cells, as well as their localization close to splenic B cells, but wasnot required for early Tfh-cell development. Finally, IL-6 promoted parasite control, IgM and IgG production, GC B-cell development and ICOS expression by Tfh cells in a second model, Py17XNL infection. IL-6 promotes CD4(+) T-cell activation and B-cell responses during blood-stage Plasmodium infection, which encourages parasite-specific antibody production.
Keyword Follicular Helper-Cell
Chabaudi-Chabaudi Infection
Germinal Center Responses
Uncomplicated Malaria
Falciparum Malaria
Q-Index Code C1
Q-Index Status Provisional Code
Grant ID 1028634
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: HERDC Pre-Audit
School of Medicine Publications
UQ Diamantina Institute Publications
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Created: Sun, 26 Nov 2017, 14:57:05 EST