Cardiorespiratory fitness modulates the acute flow-mediated dilation response following high-intensity but not moderate-intensity exercise in elderly men

Bailey, Tom G., Perissiou, Maria, Windsor, Mark, Russell, Fraser, Golledge, Jonathan, Green, Daniel J. and Askew, Christopher D. (2017) Cardiorespiratory fitness modulates the acute flow-mediated dilation response following high-intensity but not moderate-intensity exercise in elderly men. Journal of Applied Physiology, 122 5: 1238-1248. doi:10.1152/japplphysiol.00935.2016


Author Bailey, Tom G.
Perissiou, Maria
Windsor, Mark
Russell, Fraser
Golledge, Jonathan
Green, Daniel J.
Askew, Christopher D.
Title Cardiorespiratory fitness modulates the acute flow-mediated dilation response following high-intensity but not moderate-intensity exercise in elderly men
Journal name Journal of Applied Physiology   Check publisher's open access policy
ISSN 1522-1601
8750-7587
Publication date 2017-05-01
Sub-type Article (original research)
DOI 10.1152/japplphysiol.00935.2016
Open Access Status Not yet assessed
Volume 122
Issue 5
Start page 1238
End page 1248
Total pages 11
Place of publication Bethesda, MD, United States
Publisher American Physiological Society
Language eng
Subject 1314 Physiology
2737 Physiology (medical)
Abstract Impaired endothelial function is observed with aging and in those with low cardiorespiratory fitness (V̇o2peak). Improvements in endothelial function with exercise training are somewhat dependent on the intensity of exercise. While the acute stimulus for this improvement is not completely understood, it may, in part, be due to the flow-mediated dilation (FMD) response to acute exercise. We examined the hypothesis that exercise intensity alters the brachial (systemic) FMD response in elderly men and is modulated by V̇o2peak Forty-seven elderly men were stratified into lower (V̇o2peak = 24.3 ± 2.9 ml·kg-1·min-1; n = 27) and higher fit groups (V̇o2peak = 35.4 ± 5.5 ml·kg-1·min-1; n = 20) after a test of cycling peak power output (PPO). In randomized order, participants undertook moderate-intensity continuous exercise (MICE; 40% PPO) or high-intensity interval cycling exercise (HIIE; 70% PPO) or no-exercise control. Brachial FMD was assessed at rest and 10 and 60 min after exercise. FMD increased after MICE in both groups {increase of 0.86% [95% confidence interval (CI), 0.17-1.56], P = 0.01} and normalized after 60 min. In the lower fit group, FMD was reduced after HIIE [reduction of 0.85% (95% CI, 0.12-1.58), P = 0.02] and remained decreased at 60 min. In the higher fit group, FMD was unchanged immediately after HIIE and increased after 60 min [increase of 1.52% (95% CI, 0.41-2.62), P < 0.01, which was correlated with V̇o2peak, r = 0.41; P < 0.01]. In the no-exercise control, FMD was reduced in both groups after 60 min (P = 0.05). Exercise intensity alters the acute FMD response in elderly men and V̇o2peak modulates the FMD response following HIIE but not MICE. The sustained decrease in FMD in the lower fit group following HIIE may represent a signal for vascular adaptation or endothelial fatigue.NEW & NOTEWORTHY This study is the first to show that moderate-intensity continuous cycling exercise increased flow-mediated dilation (FMD) transiently before normalization of FMD after 1 h, irrespective of cardiorespiratory fitness level in elderly men. Interestingly, we show increased FMD after high-intensity cycling exercise in higher fit men, with a sustained reduction in FMD in lower fit men. The prolonged reduction in FMD after high-intensity cycling exercise may be associated with future vascular adaptation but may also reflect a period of increased cardiovascular risk in lower fit elderly men.
Keyword FMD
Aging
Cardiorespiratory fitness
Endothelial function
Exercise
Q-Index Code C1
Q-Index Status Provisional Code
Grant ID 1000967
1003707
1020955
1021416
1022752
1090914
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: HERDC Pre-Audit
School of Human Movement and Nutrition Sciences Publications
 
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Created: Wed, 15 Nov 2017, 13:53:17 EST