Magnetic resonance spin-spin relaxation time estimation in a rat model of fatty liver disease.

Alghamdi, Sami, Sinclair, Benjamin, Cowin, Gary, Brereton, Ian and Tesiram, Yasvir A (2017) Magnetic resonance spin-spin relaxation time estimation in a rat model of fatty liver disease.. Journal of magnetic resonance imaging : JMRI, . doi:10.1002/jmri.25786


Author Alghamdi, Sami
Sinclair, Benjamin
Cowin, Gary
Brereton, Ian
Tesiram, Yasvir A
Title Magnetic resonance spin-spin relaxation time estimation in a rat model of fatty liver disease.
Journal name Journal of magnetic resonance imaging : JMRI   Check publisher's open access policy
ISSN 1522-2586
Publication date 2017-06-22
Sub-type Article (original research)
DOI 10.1002/jmri.25786
Open Access Status Not yet assessed
Abstract To compare mono- and bi-exponential relaxation model equations to discriminate between normal and fatty liver disease.

Six rats on a choline deficient amino acid modified (CDAA) diet and six on normal chow were studied. Multiple spin echo images with increasing echo times (TEs) were collected at 9.4T. Pixel-wise T2 maps were generated using mono-exponential decay function to calculate T2M , and a bi-exponential to calculate, short T2 component (T2S ), long T2 component (T2L ), and fractions of these components (ρS , ρL ), respectively. Statistical F-tests and Akaike's information criterion (AIC) were used to assess the relative performance of the two models.

F-test and AIC showed that in the CDAA group, T2 bi-exponential model described the signal of T2 weighted imaging of the liver better than the mono-exponential model. Controls were best described by the mono-exponential model. Mean values for T2M , T2L , T2S , ρS , ρL were 31.2 ± 0.7 ms, 72.8 ± 3.3 ms, 8.2 ± 0.6 ms,71.2 ± 2.1%, 30.4 ± 1.3%, respectively, in CDAA rats, compared with 18.8 ± 0.5 ms, 32.3 ± 0.7 ms, 9.2 ± 1.8 ms, 79 ± 2%, 21.0 ± 1.1% in controls.

In the fatty liver of CDAA rats we have shown that T2 weighted images fit the bi-exponential model better than mono-exponential decays thus providing a better description of the data.

1 Technical Efficacy: Stage 2 J. Magn. Reson. Imaging 2017.
Keyword MRI
T2 relaxation; mono- & bi-exponential function
choline deficient rat
fat fraction
fatty liver disease
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: Pubmed Import
 
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Created: Wed, 15 Nov 2017, 13:47:45 EST