Recent Advances in the Generation of Antibody-Nanomaterial Conjugates

Sivaram, Amal J, Wardiana, Andri, Howard, Christopher B, Mahler, Stephen M and Thurecht, Kristofer J (2017) Recent Advances in the Generation of Antibody-Nanomaterial Conjugates. Advanced healthcare materials, 7 1: 1-25. doi:10.1002/adhm.201700607

Author Sivaram, Amal J
Wardiana, Andri
Howard, Christopher B
Mahler, Stephen M
Thurecht, Kristofer J
Title Recent Advances in the Generation of Antibody-Nanomaterial Conjugates
Journal name Advanced healthcare materials   Check publisher's open access policy
ISSN 2192-2659
Publication date 2017-09-29
Year available 2017
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1002/adhm.201700607
Open Access Status Not yet assessed
Volume 7
Issue 1
Start page 1
End page 25
Total pages 25
Place of publication Weinheim, Germany
Publisher Wiley-VCH Verlag
Language eng
Subject 2502 Biomaterials
2204 Biomedical Engineering
3003 Pharmaceutical Science
Abstract Targeted nanomedicines have significantly changed the way new therapeutics are designed to treat disease. Central to successful therapeutics is the ability to control the dynamics of protein-nanomaterial interactions to enhance the therapeutic effect of the nanomedicine. The aim of this review is to illustrate the diversity and versatility of the conjugation approaches involved in the synthesis of antibody-nanoparticle conjugates, and highlight significant new advances in the field of bioconjugation. Such nanomedicines have found utility as both advanced therapeutic agents, as well as more complex imaging contrast agents that can provide both anatomical and functional information of diseased tissue. While such conjugates show significant promise as next generation targeted nanomedicines, it is recognized that there are in fact no clinically approved targeted therapeutics on the market. This fact is reflected upon within this review, and attempts are made to draw some reasoning from the complexities associated with the bioconjugation chemistry approaches that are typically utilized. Present trends, as well as future directions of next generation targeted nanomedicines are also discussed.
Keyword ScFvs
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: Australian Institute for Bioengineering and Nanotechnology Publications
Centre for Advanced Imaging Publications
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 0 times in Thomson Reuters Web of Science Article
Scopus Citation Count Cited 0 times in Scopus Article
Google Scholar Search Google Scholar
Created: Wed, 15 Nov 2017, 13:40:25 EST