Recent Advances in the Generation of Antibody-Nanomaterial Conjugates.

Sivaram, Amal J, Wardiana, Andri, Howard, Christopher B, Mahler, Stephen M and Thurecht, Kristofer J (2017) Recent Advances in the Generation of Antibody-Nanomaterial Conjugates.. Advanced healthcare materials, . doi:10.1002/adhm.201700607


Author Sivaram, Amal J
Wardiana, Andri
Howard, Christopher B
Mahler, Stephen M
Thurecht, Kristofer J
Title Recent Advances in the Generation of Antibody-Nanomaterial Conjugates.
Journal name Advanced healthcare materials   Check publisher's open access policy
ISSN 2192-2659
Publication date 2017-09-29
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1002/adhm.201700607
Open Access Status Not yet assessed
Abstract Targeted nanomedicines have significantly changed the way new therapeutics are designed to treat disease. Central to successful therapeutics is the ability to control the dynamics of protein-nanomaterial interactions to enhance the therapeutic effect of the nanomedicine. The aim of this review is to illustrate the diversity and versatility of the conjugation approaches involved in the synthesis of antibody-nanoparticle conjugates, and highlight significant new advances in the field of bioconjugation. Such nanomedicines have found utility as both advanced therapeutic agents, as well as more complex imaging contrast agents that can provide both anatomical and functional information of diseased tissue. While such conjugates show significant promise as next generation targeted nanomedicines, it is recognized that there are in fact no clinically approved targeted therapeutics on the market. This fact is reflected upon within this review, and attempts are made to draw some reasoning from the complexities associated with the bioconjugation chemistry approaches that are typically utilized. Present trends, as well as future directions of next generation targeted nanomedicines are also discussed.
Keyword ScFvs
antibodies
bioconjugation
nanoparticles
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collection: Pubmed Import
 
Versions
Version Filter Type
Citation counts: Google Scholar Search Google Scholar
Created: Wed, 15 Nov 2017, 13:40:25 EST