Exploring the molecular mechanisms of parasite-host interactions with a view towards new therapeutics and vaccines

Cross, Megan, Klepzig, Emma, Dallaston, Madeleine, Young, Neil D., Bailey, Ulla-Maja, Mason, Lyndel, Jones, Malcolm K, Gasser, Robin B and Hofmann, Andreas (2016) Exploring the molecular mechanisms of parasite-host interactions with a view towards new therapeutics and vaccines. Postepy Biochemii, 62 3: 370-376.

Author Cross, Megan
Klepzig, Emma
Dallaston, Madeleine
Young, Neil D.
Bailey, Ulla-Maja
Mason, Lyndel
Jones, Malcolm K
Gasser, Robin B
Hofmann, Andreas
Title Exploring the molecular mechanisms of parasite-host interactions with a view towards new therapeutics and vaccines
Journal name Postepy Biochemii
ISSN 0032-5422
Publication date 2016-01-01
Sub-type Critical review of research, literature review, critical commentary
Open Access Status Not yet assessed
Volume 62
Issue 3
Start page 370
End page 376
Total pages 7
Place of publication Warsaw, Poland
Publisher Polish Biochemical Society
Language eng
Subject 2700 Medicine
Abstract Despite the massive disease burden worldwide caused by parasitic nematodes and other infectious pathogens, the molecular basis of many infectious diseases caused by these pathogens has been unduly neglected for a long time. Therefore, accelerated progress towards novel therapeutics, and ultimately control of such infectious diseases, is of crucial importance. Capitalising on the wealth of data becoming available from proteomic and genomic studies, new protein targets at the pathogen-host interface can be identified and subjected to protein-based explorations of the molecular basis of pathogen-host interactions. By combining the use of systems and structural biology methodologies, insights into the structural and molecular mechanisms of these interactions can assist in the development of therapeutics and/or vaccines. This brief review examines two different proteins from the body wall of blood flukes - annexins and the stress-induced phosphoprotein 1 - both of which are presently interesting targets for the development of therapeutics.
Keyword Helminths
Parasite-host interface
Tegument proteins
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: HERDC Pre-Audit
School of Veterinary Science Publications
 
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Created: Wed, 15 Nov 2017, 12:44:56 EST