Comparing the Immune-Genomic Effects of Vilazodone and Paroxetine in Late-Life Depression: A Pilot Study.

Eyre, Harris, Siddarth, Prabha, Cyr, Natalie, Yang, Hongyu, Cole, Steve, Forbes, Malcolm and Lavretsky, Helen (2017) Comparing the Immune-Genomic Effects of Vilazodone and Paroxetine in Late-Life Depression: A Pilot Study.. Pharmacopsychiatry, 50 6: 256-263. doi:10.1055/s-0043-107033


Author Eyre, Harris
Siddarth, Prabha
Cyr, Natalie
Yang, Hongyu
Cole, Steve
Forbes, Malcolm
Lavretsky, Helen
Title Comparing the Immune-Genomic Effects of Vilazodone and Paroxetine in Late-Life Depression: A Pilot Study.
Journal name Pharmacopsychiatry   Check publisher's open access policy
ISSN 1439-0795
Publication date 2017-11-01
Sub-type Article (original research)
DOI 10.1055/s-0043-107033
Open Access Status Not yet assessed
Volume 50
Issue 6
Start page 256
End page 263
Total pages 8
Abstract Vilazodone is a novel antidepressant agent that combines selective serotonin (5-HT) reuptake inhibitor (SSRI) activity and 5-HT(1A) receptor partial agonist activity. A pilot study was conducted to compare vilazodone (novel compound) and paroxetine (gold standard) on antidepressant effects, tolerability, and inflammation and immune modulation. A 12-week, double-blind, randomized clinical trial was conducted with 56 nondemented older adults diagnosed with major depressive disorder (MDD). Between-group differences in mood, tolerability, and safety, as well as genomic markers of inflammation and immune modulation, were examined. Both treatment groups demonstrated similar improvement in depressed mood. Leukocyte gene expression profiles demonstrated reduction of specific proinflammatory gene transcripts and bioinformatic indications of reduced nuclear factor kappa B (NF-κB), activator protein (AP)-1, and cAMP response element binding (CREB) activity in the vilazodone group compared to the paroxetine group. Transcript origin analyses implicated monocytes and dendritic cells as the primary cellular origins of transcript reductions in the vilazodone-treated group. Vilazodone's antidepressant effects may be associated with reduction of proinflammatory gene expression and immune modulation. Further research is required.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: Pubmed Import
 
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Created: Wed, 15 Nov 2017, 12:38:51 EST