The impact of carboxy nitroxide antioxidants on irradiated ataxia telangiectasia cells

Hosokawa, K, Chen, P, Lavin, MF and Bottle, SE (2004) The impact of carboxy nitroxide antioxidants on irradiated ataxia telangiectasia cells. Free Radical Biology And Medicine, 37 7: 946-952. doi:10.1016/j.freeradbiomed.2004.06.035


Author Hosokawa, K
Chen, P
Lavin, MF
Bottle, SE
Title The impact of carboxy nitroxide antioxidants on irradiated ataxia telangiectasia cells
Journal name Free Radical Biology And Medicine   Check publisher's open access policy
ISSN 0891-5849
Publication date 2004-01-01
Sub-type Article (original research)
DOI 10.1016/j.freeradbiomed.2004.06.035
Volume 37
Issue 7
Start page 946
End page 952
Total pages 7
Editor K. J. A. Davies
W. A. Pryor
Place of publication Oxford, U.K.
Publisher Elsevier Inc
Language eng
Subject C1
321204 Mental Health
730204 Child health
Abstract Three water-soluble carboxy nitroxide antioxidants, 5-carboxy-1,1,3,3-tetramethylisoindolin-2-yloxyl, 4-carboxy-2,2,6,6-tetramethylpiperidin-1-yloxyl, and 3-carboxy-2,2,5,5-tetramethylpyrrolidin-1-yloxyl, show significant impact on the postirradiation survival rates of ataxia telangiectasia (A-T) cells compared to normal cells, an assay which represents a model for understanding the impact of ROS damage on the A-T phenotype. The effects of these antioxidants are much more significant than those of vitamin E or Trolox (a water-soluble vitamin E analog), studied using the same cell survival model. (C) 2004 Elsevier Inc. All rights reserved.
Keyword Biochemistry & Molecular Biology
Endocrinology & Metabolism
Nitroxide
Ataxia Telangiectasia
Antioxidant
Ros
Free Radical
Oxidative Stress
Dna-damage
Free-radicals
Atm
Mice
Gene
Q-Index Code C1

Document type: Journal Article
Sub-type: Article (original research)
Collections: Excellence in Research Australia (ERA) - Collection
2005 Higher Education Research Data Collection
School of Medicine Publications
 
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Created: Wed, 15 Aug 2007, 13:23:59 EST