Novel Therapeutics for Multiple Sclerosis Designed by Parasitic Worms

Dixit, Aakanksha, Tanaka, Akane, Greer, Judith M and Donnelly, Sheila (2017) Novel Therapeutics for Multiple Sclerosis Designed by Parasitic Worms. International Journal of Molecular Sciences, 18 10: 1-17. doi:10.3390/ijms18102141


Author Dixit, Aakanksha
Tanaka, Akane
Greer, Judith M
Donnelly, Sheila
Title Novel Therapeutics for Multiple Sclerosis Designed by Parasitic Worms
Journal name International Journal of Molecular Sciences   Check publisher's open access policy
ISSN 1422-0067
1424-6783
1661-6596
Publication date 2017-10-13
Year available 2017
Sub-type Critical review of research, literature review, critical commentary
DOI 10.3390/ijms18102141
Open Access Status DOI
Volume 18
Issue 10
Start page 1
End page 17
Total pages 17
Place of publication Basel, Switzerland
Publisher MDPI AG
Language eng
Abstract The evolutionary response to endemic infections with parasitic worms (helminth) was the development of a distinct regulatory immune profile arising from the need to encapsulate the helminths while simultaneously repairing tissue damage. According to the old friend's hypothesis, the diminished exposure to these parasites in the developed world has resulted in a dysregulated immune response that contributes to the increased incidence of immune mediated diseases such as Multiple Sclerosis (MS). Indeed, the global distribution of MS shows an inverse correlation to the prevalence of helminth infection. On this basis, the possibility of treating MS with helminth infection has been explored in animal models and phase 1 and 2 human clinical trials. However, the possibility also exists that the individual immune modulatory molecules secreted by helminth parasites may offer a more defined therapeutic strategy.
Keyword environmental factors
helminth parasites
immune modulation
innate immunity
multiple sclerosis
old friend’s hypothesis
Q-Index Code C1
Q-Index Status Provisional Code
Grant ID 15-033
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: UQ Centre for Clinical Research Publications
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Created: Wed, 15 Nov 2017, 12:13:55 EST