Burn pain: a systematic and critical review of epidemiology, pathophysiology, and treatment

Morgan, Michael, Deuis, Jennifer R., Frøsig-Jørgensen, Majbrit, Lewis, Richard J., Cabot, Peter J., Gray, Paul D. and Vetter, Irina (2017) Burn pain: a systematic and critical review of epidemiology, pathophysiology, and treatment. Pain Medicine, 19 4: 708-734. doi:10.1093/pm/pnx228


Author Morgan, Michael
Deuis, Jennifer R.
Frøsig-Jørgensen, Majbrit
Lewis, Richard J.
Cabot, Peter J.
Gray, Paul D.
Vetter, Irina
Title Burn pain: a systematic and critical review of epidemiology, pathophysiology, and treatment
Journal name Pain Medicine   Check publisher's open access policy
ISSN 1526-4637
1526-2375
Publication date 2017-09-23
Year available 2017
Sub-type Article (original research)
DOI 10.1093/pm/pnx228
Open Access Status Not yet assessed
Volume 19
Issue 4
Start page 708
End page 734
Total pages 27
Place of publication Cary, NC United States
Publisher Oxford University Press
Language eng
Abstract This review aims to examine the available literature on the epidemiology, pathophysiology, and treatment of burn-induced pain.

A search was conducted on the epidemiology of burn injury and treatment of burn pain utilizing the database Medline, and all relevant articles were systemically reviewed. In addition, a critical review was performed on the pathophysiology of burn pain and animal models of burn pain.

The search on the epidemiology of burn injury yielded a total of 163 publications of interest, 72 of which fit the inclusion/exclusion criteria, with no publications providing epidemiological data on burn injury pain management outcomes. The search on the treatment of burn pain yielded a total of 213 publications, 14 of which fit the inclusion/exclusion criteria, highlighting the limited amount of evidence available on the treatment of burn-induced pain.

The pathophysiology of burn pain is poorly understood, with limited clinical trials available to assess the effectiveness of analgesics in burn patients. Further studies are needed to identify new pharmacological targets and treatments for the effective management of burn injury pain.
Formatted abstract
Objective
 This review aims to examine the available literature on the epidemiology, pathophysiology, and treatment of burn-induced pain.

Methods
 A search was conducted on the epidemiology of burn injury and treatment of burn pain utilizing the database Medline, and all relevant articles were systemically reviewed. In addition, a critical review was performed on the pathophysiology of burn pain and animal models of burn pain.

Results
 The search on the epidemiology of burn injury yielded a total of 163 publications of interest, 72 of which fit the inclusion/exclusion criteria, with no publications providing epidemiological data on burn injury pain management outcomes. The search on the treatment of burn pain yielded a total of 213 publications, 14 of which fit the inclusion/exclusion criteria, highlighting the limited amount of evidence available on the treatment of burn-induced pain.

Conclusions
 The pathophysiology of burn pain is poorly understood, with limited clinical trials available to assess the effectiveness of analgesics in burn patients. Further studies are needed to identify new pharmacological targets and treatments for the effective management of burn injury pain.
Keyword Analgesia
Burn pain
Inflammation
Mechanisms
Neuropathic pain
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: HERDC Pre-Audit
Faculty of Medicine
School of Pharmacy Publications
Institute for Molecular Bioscience - Publications
 
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Created: Wed, 15 Nov 2017, 12:13:00 EST