Influence of insulin on growth hormone secretion, level and growth hormone signalling

Qiu, Han, Yang, Jin-Kui and Chen, Chen (2017) Influence of insulin on growth hormone secretion, level and growth hormone signalling. Sheng Li Xue Bao : [Acta physiologica Sinica], 69 5: 541-556.

Author Qiu, Han
Yang, Jin-Kui
Chen, Chen
Title Influence of insulin on growth hormone secretion, level and growth hormone signalling
Journal name Sheng Li Xue Bao : [Acta physiologica Sinica]   Check publisher's open access policy
ISSN 0371-0874
Publication date 2017-10-25
Year available 2017
Sub-type Article (original research)
Open Access Status Not yet assessed
Volume 69
Issue 5
Start page 541
End page 556
Total pages 16
Place of publication Beijing, China
Publisher Kexue Chubanshe / Science Press
Abstract Growth hormone (GH), as a vital hormone, has to experience a series of processes to fulfill its function including secretion, entering the circulation to reach target tissues (pre-receptor process), binding on the GH receptor (GHR) and triggering signaling inside cells (post-GHR process). Insulin can directly or indirectly influence part of these processes. GH secretion from pituitary somatotropes is regulated by GH-releasing hormone (GHRH) and somatostatin (SS) from hypothalamus. Insulin may exert positive or negative effects on the neurons expressing GHRH and SS and somatotropes under healthy and pathological conditions including obesity and diabetes. Glucose and lipid levels in circulation and dietary habits may influence the effect of insulin on GH secretion. Insulin may also affect GHR sensitivity and the level of insulin-like growth factor 1 (IGF-1), thus influence the level of GH. The GH signaling is also important for GH to play its role. GH signaling involves GHR/JAK2/STATs, GHR/JAK2/SHC/MAPK and GH/insulin receptor substrate (IRS)/PI3K/Akt pathways. These pathways may be shared by insulin, which is the basis for the interaction between insulin and GH, and insulin may attenuate or facilitate the GH signal by influencing molecules in the pathways. Many factors are related to the effect of insulin, among them the most important ones are duration of action and amount of insulin. The tendency of insulin-reduced GH signaling becomes obvious with increased dose and acting time of insulin. The participation of suppressor of cytokine signaling (SOCS), the interaction between JAK2 and IRS, and GHR sensitivity should also be considered when discovering GH signal. The involvement of SS in response to insulin is not clear yet. The details of how GH secretion, level and signaling change in response to time and dose of insulin treatment warrant further studies.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: HERDC Pre-Audit
School of Biomedical Sciences Publications
Version Filter Type
Citation counts: Google Scholar Search Google Scholar
Created: Wed, 15 Nov 2017, 12:09:09 EST