Hair Cortisol in Twins: Heritability and Genetic Overlap with Psychological Variables and Stress-System Genes

Rietschel, Liz, Streit, Fabian, Zhu, Gu, McAloney, Kerrie, Frank, Josef, Couvy-Duchesne, Baptiste, Witt, Stephanie H., Binz, Tina M., Bolton, Jennifer L., Hayward, Caroline, Direk, Nese, Anderson, Anna, Huffman, Jennifer, Wilson, James F., Campbell, Harry, Rudan, Igor, Wright, Alan, Hastie, Nicholas, Wild, Sarah H., Velders, Fleur P., Hofman, Albert, Uitterlinden, Andre G., Lahti, Jari, Räikkönen, Katri, Kajantie, Eero, Widen, Elisabeth, Palotie, Aarno, Eriksson, Johan G., Kaakinen, Marika, Järvelin, Marjo-Riitta, Timpson, Nicholas J., Davey Smith, George, Ring, Susan M., Evans, David M., St Pourcain, Beate, Tanaka, Toshiko, Milaneschi, Yuri, Bandinelli, Stefania, Ferrucci, Luigi, Van Der Harst, Pim, Rosmalen, Judith Gm, Bakker, Stephen Jl, Verweij, Niek, Dullaart, Robin Pf, Mahajan, Anubha, Lindgren, Cecilia M., Morris, Andrew, Lind, Lars, Ingelsson, Erik, Anderson, Laura N., Pennell, Craig E., Lye, Stephen J., Matthews, Stephen G., Eriksson, Joel, Mellstrom, Dan, Ohlsson, Claes, Price, Jackie F., Strachan, Mark Wj, Reynolds, Rebecca M., Tiemeier, Henning, Ripke, Stephan, Mattheisen, Manuel, Abdellaoui, Abdel, Adams, Mark J., Agerbo, Esben, Air, Tracy M., Andlauer, Till Fm, Bacanu, Silviu-Alin, Bækvad-Hansen, Marie, Beekman, Aartjan Tf, Bennett, David A., Berger, Klaus, Bigdeli, Tim B., Bybjerg-Grauholm, Jonas, Byrne, Enda M., Cai, Na, Castelao, Enrique, Clarke, Toni-Kim, Coleman, Jonathan Ri, Consortium, Converge, Craddock, Nick, Dannlowski, Udo, Davies, Gareth, Davies, Gail, De Geus, Eco. J. C., De Jager, Philip, Deary, Ian J., Degenhardt, Franziska, Dunn, Erin C., Ehli, Erik A., Eley, Thalia C., Escott-Price, Valentina, Esko, Tõnu, Finucane, Hilary K., Gill, Michael, Gordon, Scott D., Grove, Jakob, Hall, Lynsey S., Hansen, Thomas F., Søholm Hansen, Christine, Heath, Andrew C., Henders, Anjali K., Herms, Stefan, Hoffmann, Per, Homuth, Georg, Horn, Carsten, Hottenga, Jouke-Jan, Hougaard, David, Huang, Hailiang, Ising, Marcus, Jansen, Rick, Jorgenson, Eric, Kloiber, Stefan, Knowles, James A, Kretzschmar, Warren W., Krogh, Jesper, Kutalik, Zoltán, Lang, Maren, Lewis, Glyn, Li, Yihan, MacIntyre, Donald J., Madden, Pamela Af, Marchine, Jonathan, Mbarek, Hamdi, McGuffin, Peter, Mehta, Divya, Metspalu, Andres, Middeldorp, Christel M., Mihailov, Evelin, Milani, Lili, Montgomery, Grant W., Mostafavi, Sara, Mullins, Niamh, Nauck, Matthias, Ng, Bernard, Nordentoft, Merete, Nyholt, Dale R., O'Donovan, Michael C., O'Reilly, Paul F., Oskarsson, Hogni, Owen, Michael J., Paciga, Sara A., Pedersen, Carsten Bøcker, Pedersen, Marianne Giørtz, Pedersen, Nancy L., Pergadia, Michele L., Peterson, Roseann E., Pettersson, Erik, Peyrot, Wouter J., Porteous, David J., Posthuma, Danielle, Potash, James B., Quiroz, Jorge A., Rice, John P., Riley, Brien P., Rivera, Margarita, Ruderfer, Douglas M., Saeed Mirza, Saira, Schoevers, Robert, Shen, Ling, Shi, Jianxin, Sigurdsson, Engilbert, Sinnamon, Grant Cb, Smit, Johannes H., Smith, Daniel J., Stephansson, Hreinn, Steinberg, Stacy, Strohmaier, Jana, Tansey, Katherine E., Teumer, Alexander, Thompson, Wesley, Thomson, Pippa A., Thorgeirsson, Thorgeir E., Treutlein, Jens, Trzaskowski, Maciej, Umbricht, Daniel, Van Der Auwera, Sandra, Van Grootheest, Gerard, Van Hemert, Albert M., Viktorin, Alexander, Völzke, Henry, Wang, Yunpeng, Webb, Bradley T., Weissman, Myrna M., Wellmann, Jürgen, Willemsen, Gonneke, Xi, Hualin S., Baune, Bernhard T., Blackwood, Douglas H. R., Boomsma, Dorret I., Børglum, Anders D., Buttenschøn, Henriette N., Cichon, Sven, Domenici, Enrico, Flint, Jonathan, Grabe, Hans J., Hamilton, Steven P., Kendler, Kenneth S., Li, Qingqin S., Lucae, Susanne, Magnusson, Patrik K., McIntosh, Andrew M., Mors, Ole, Bo Mortensen, Preben, Müller-Myhsok, Bertram, Penninx, Brenda Wjh, Perlis, Roy H., Preisig, Martin, Schaefer, Catherine, Smoller, Jordan W., Stephansson, Kari, Uher, Rudolf, Werge, Thomas, Winslow, Ashley R., Breen, Gerome, Levinson, Douglas F., Lewis, Cathryn M., Wray, Naomi R., Sullivan, Patrick F., McGrath, John, Hickie, Ian B., Hansell, Narelle K., Wright, Margaret J., Gillespie, Nathan A., Forstner, Andreas J., Schulze, Thomas G, Wüst, Stefan, Nöthen, Markus M., Baumgartner, Markus R., Walker, Brian R., Crawford, Andrew A., Colodro-Conde, Lucía, Medland, Sarah E., Martin, Nicholas G. and Rietschel, Marcella (2017) Hair Cortisol in Twins: Heritability and Genetic Overlap with Psychological Variables and Stress-System Genes. Scientific reports, 7 1: 15351. doi:10.1038/s41598-017-11852-3


Author Rietschel, Liz
Streit, Fabian
Zhu, Gu
McAloney, Kerrie
Frank, Josef
Couvy-Duchesne, Baptiste
Witt, Stephanie H.
Binz, Tina M.
Bolton, Jennifer L.
Hayward, Caroline
Direk, Nese
Anderson, Anna
Huffman, Jennifer
Wilson, James F.
Campbell, Harry
Rudan, Igor
Wright, Alan
Hastie, Nicholas
Wild, Sarah H.
Velders, Fleur P.
Hofman, Albert
Uitterlinden, Andre G.
Lahti, Jari
Räikkönen, Katri
Kajantie, Eero
Widen, Elisabeth
Palotie, Aarno
Eriksson, Johan G.
Kaakinen, Marika
Järvelin, Marjo-Riitta
Timpson, Nicholas J.
Davey Smith, George
Ring, Susan M.
Evans, David M.
St Pourcain, Beate
Tanaka, Toshiko
Milaneschi, Yuri
Bandinelli, Stefania
Ferrucci, Luigi
Van Der Harst, Pim
Rosmalen, Judith Gm
Bakker, Stephen Jl
Verweij, Niek
Dullaart, Robin Pf
Mahajan, Anubha
Lindgren, Cecilia M.
Morris, Andrew
Lind, Lars
Ingelsson, Erik
Anderson, Laura N.
Pennell, Craig E.
Lye, Stephen J.
Matthews, Stephen G.
Eriksson, Joel
Mellstrom, Dan
Ohlsson, Claes
Price, Jackie F.
Strachan, Mark Wj
Reynolds, Rebecca M.
Tiemeier, Henning
Ripke, Stephan
Mattheisen, Manuel
Abdellaoui, Abdel
Adams, Mark J.
Agerbo, Esben
Air, Tracy M.
Andlauer, Till Fm
Bacanu, Silviu-Alin
Bækvad-Hansen, Marie
Beekman, Aartjan Tf
Bennett, David A.
Berger, Klaus
Bigdeli, Tim B.
Bybjerg-Grauholm, Jonas
Byrne, Enda M.
Cai, Na
Castelao, Enrique
Clarke, Toni-Kim
Coleman, Jonathan Ri
Consortium, Converge
Craddock, Nick
Dannlowski, Udo
Davies, Gareth
Davies, Gail
De Geus, Eco. J. C.
De Jager, Philip
Deary, Ian J.
Degenhardt, Franziska
Dunn, Erin C.
Ehli, Erik A.
Eley, Thalia C.
Escott-Price, Valentina
Esko, Tõnu
Finucane, Hilary K.
Gill, Michael
Gordon, Scott D.
Grove, Jakob
Hall, Lynsey S.
Hansen, Thomas F.
Søholm Hansen, Christine
Heath, Andrew C.
Henders, Anjali K.
Herms, Stefan
Hoffmann, Per
Homuth, Georg
Horn, Carsten
Hottenga, Jouke-Jan
Hougaard, David
Huang, Hailiang
Ising, Marcus
Jansen, Rick
Jorgenson, Eric
Kloiber, Stefan
Knowles, James A
Kretzschmar, Warren W.
Krogh, Jesper
Kutalik, Zoltán
Lang, Maren
Lewis, Glyn
Li, Yihan
MacIntyre, Donald J.
Madden, Pamela Af
Marchine, Jonathan
Mbarek, Hamdi
McGuffin, Peter
Mehta, Divya
Metspalu, Andres
Middeldorp, Christel M.
Mihailov, Evelin
Milani, Lili
Montgomery, Grant W.
Mostafavi, Sara
Mullins, Niamh
Nauck, Matthias
Ng, Bernard
Nordentoft, Merete
Nyholt, Dale R.
O'Donovan, Michael C.
O'Reilly, Paul F.
Oskarsson, Hogni
Owen, Michael J.
Paciga, Sara A.
Pedersen, Carsten Bøcker
Pedersen, Marianne Giørtz
Pedersen, Nancy L.
Pergadia, Michele L.
Peterson, Roseann E.
Pettersson, Erik
Peyrot, Wouter J.
Porteous, David J.
Posthuma, Danielle
Potash, James B.
Quiroz, Jorge A.
Rice, John P.
Riley, Brien P.
Rivera, Margarita
Ruderfer, Douglas M.
Saeed Mirza, Saira
Schoevers, Robert
Shen, Ling
Shi, Jianxin
Sigurdsson, Engilbert
Sinnamon, Grant Cb
Smit, Johannes H.
Smith, Daniel J.
Stephansson, Hreinn
Steinberg, Stacy
Strohmaier, Jana
Tansey, Katherine E.
Teumer, Alexander
Thompson, Wesley
Thomson, Pippa A.
Thorgeirsson, Thorgeir E.
Treutlein, Jens
Trzaskowski, Maciej
Umbricht, Daniel
Van Der Auwera, Sandra
Van Grootheest, Gerard
Van Hemert, Albert M.
Viktorin, Alexander
Völzke, Henry
Wang, Yunpeng
Webb, Bradley T.
Weissman, Myrna M.
Wellmann, Jürgen
Willemsen, Gonneke
Xi, Hualin S.
Baune, Bernhard T.
Blackwood, Douglas H. R.
Boomsma, Dorret I.
Børglum, Anders D.
Buttenschøn, Henriette N.
Cichon, Sven
Domenici, Enrico
Flint, Jonathan
Grabe, Hans J.
Hamilton, Steven P.
Kendler, Kenneth S.
Li, Qingqin S.
Lucae, Susanne
Magnusson, Patrik K.
McIntosh, Andrew M.
Mors, Ole
Bo Mortensen, Preben
Müller-Myhsok, Bertram
Penninx, Brenda Wjh
Perlis, Roy H.
Preisig, Martin
Schaefer, Catherine
Smoller, Jordan W.
Stephansson, Kari
Uher, Rudolf
Werge, Thomas
Winslow, Ashley R.
Breen, Gerome
Levinson, Douglas F.
Lewis, Cathryn M.
Wray, Naomi R.
Sullivan, Patrick F.
McGrath, John
Hickie, Ian B.
Hansell, Narelle K.
Wright, Margaret J.
Gillespie, Nathan A.
Forstner, Andreas J.
Schulze, Thomas G
Wüst, Stefan
Nöthen, Markus M.
Baumgartner, Markus R.
Walker, Brian R.
Crawford, Andrew A.
Colodro-Conde, Lucía
Medland, Sarah E.
Martin, Nicholas G.
Rietschel, Marcella
Title Hair Cortisol in Twins: Heritability and Genetic Overlap with Psychological Variables and Stress-System Genes
Journal name Scientific reports   Check publisher's open access policy
ISSN 2045-2322
Publication date 2017-11-10
Year available 2017
Sub-type Article (original research)
DOI 10.1038/s41598-017-11852-3
Open Access Status DOI
Volume 7
Issue 1
Start page 15351
Total pages 15
Place of publication LONDON
Publisher Nature Publishing Group
Language eng
Subject 1000 General
Abstract Hair cortisol concentration (HCC) is a promising measure of long-term hypothalamus-pituitary-adrenal (HPA) axis activity. Previous research has suggested an association between HCC and psychological variables, and initial studies of inter-individual variance in HCC have implicated genetic factors. However, whether HCC and psychological variables share genetic risk factors remains unclear. The aims of the present twin study were to: (i) assess the heritability of HCC; (ii) estimate the phenotypic and genetic correlation between HPA axis activity and the psychological variables perceived stress, depressive symptoms, and neuroticism; using formal genetic twin models and molecular genetic methods, i.e. polygenic risk scores (PRS). HCC was measured in 671 adolescents and young adults. These included 115 monozygotic and 183 dizygotic twin-pairs. For 432 subjects PRS scores for plasma cortisol, major depression, and neuroticism were calculated using data from large genome wide association studies. The twin model revealed a heritability for HCC of 72%. No significant phenotypic or genetic correlation was found between HCC and the three psychological variables of interest. PRS did not explain variance in HCC. The present data suggest that HCC is highly heritable. However, the data do not support a strong biological link between HCC and any of the investigated psychological variables.
Keyword Adrenal Axis Activity
Long-Term Cortisol
Depressive Symptoms
Perceived Stress
Intraindividual Stability
Psychiatric-Disorders
Socioeconomic-Status
Future-Directions
Morning Cortisol
Major Depression
Q-Index Code C1
Q-Index Status Provisional Code
Grant ID CZB-4-733
RG11/4/28734
107049/Z/15/Z
APP1049911
BMBF01ZX1314G
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: Pubmed Import
 
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Created: Wed, 15 Nov 2017, 12:01:14 EST