Antimicrobial and immunomodulatory surface-functionalized electrospun membranes for bone regeneration

Mathew, Asha, Vaquette, Cedryck, Hashimi, Saeed, Rathnayake, Irani, Huygens, Flavia, Hutmacher, Dietmar W. and Ivanovski, Saso (2017) Antimicrobial and immunomodulatory surface-functionalized electrospun membranes for bone regeneration. Advanced Healthcare Materials, 6 10: . doi:10.1002/adhm.201601345

Author Mathew, Asha
Vaquette, Cedryck
Hashimi, Saeed
Rathnayake, Irani
Huygens, Flavia
Hutmacher, Dietmar W.
Ivanovski, Saso
Title Antimicrobial and immunomodulatory surface-functionalized electrospun membranes for bone regeneration
Journal name Advanced Healthcare Materials   Check publisher's open access policy
ISSN 2192-2659
Publication date 2017-05-24
Year available 2017
Sub-type Article (original research)
DOI 10.1002/adhm.201601345
Open Access Status Not yet assessed
Volume 6
Issue 10
Total pages 12
Place of publication Weinheim, Germany
Publisher Wiley - V C H Verlag GmbH & Co. KGaA
Language eng
Subject 2502 Biomaterials
2204 Biomedical Engineering
3003 Pharmaceutical Science
Abstract Guided bone regeneration (GBR) is a surgical procedure utilizing occlusive membranes for providing space maintenance and enabling selective repopulation of the damaged area. While this technique is effective in regenerating bone, bacterial infiltration occurs frequently and can compromise the regenerative outcome. In this study, the authors describe the development and characterization of a GBR membrane made of medical grade polycaprolactone (mPCL) electrospun fibers with antibacterial and immunomodulatory properties. This is achieved by the immobilization of the antibiotic azithromycin into the membrane via a solvent evaporation technique leading to a sustained release of the drug over 14 d. In vitro testing shows that this controlled release of azithromycin is proficient at inhibiting the growth of Staphylococcus aureus for 14 d. Implantation of azithromycin loaded mPCL membrane in a rodent calvarial defect induces macrophage polarization toward the M2 phenotype after one week and results in significantly more bone regeneration eight weeks post-surgery. The results suggest that this antibacterial membrane should be effective at preventing infection and also impacts on the macrophage polarization enhancing bone regeneration. The drug loading technique developed in this study is simple, effective with a strong potential for clinical translation and can be applied to different types of scaffolds and implants for applications in craniofacial and orthopedics applications.
Keyword Azithromycin
Bone regeneration
Macrophage polarization
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
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School of Dentistry Publications
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