Uterotonic plants and their bioactive constituents

Gruber, Christian W. and O'Brien, Margaret (2011) Uterotonic plants and their bioactive constituents. Planta Medica, 77 3: 207-220. doi:10.1055/s-0030-1250317


Author Gruber, Christian W.
O'Brien, Margaret
Title Uterotonic plants and their bioactive constituents
Journal name Planta Medica   Check publisher's open access policy
ISSN 0032-0943
1439-0221
Publication date 2011-02-01
Year available 2011
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1055/s-0030-1250317
Open Access Status Not yet assessed
Volume 77
Issue 3
Start page 207
End page 220
Total pages 14
Place of publication Stuttgart, Germany
Publisher Georg Thieme
Language eng
Abstract Abnormalities in the process of uterine muscle contractility during pregnancy and birth can have major clinical implications, including preterm labour, which is the single largest cause of maternal and prenatal mortality in the Western world and a major contributor to childhood developmental problems. In contrast, induction of labour may be necessary in certain conditions. Currently used interventional therapies to suppress (tocolytic agents) or to induce (uterotonic agents) uterine contractions lack potency and/or selectivity and can have harmful side effects for mother and baby. Nature's diversity has always been, and still is, one of the biggest resources of therapeutic lead compounds. Many natural products exhibit biological activity against unrelated targets, thus providing researchers with starting points for drug development. In this review we will provide an overview of uterine muscle physiology, describe currently available biological screening procedures for testing of uterotonic plant compounds and will summarise traditionally-used uterotonic plants, their active components and their mechanisms, primarily focusing on uterotonic active circular plant peptides called cyclotides. Finally we will comment on the discovery of novel cyclotide-producing plant species and the possibility for the development of novel plant-derived uterotonic and tocolytic drugs.
Keyword Growth hormone releasing hormone
Human myometrial cells
Supercritical-fluid extraction
Smooth-muscle-cells
Cyclic-cystine-knot
Isolated rat uterus
Human-Fetal Membranes
Tumor-Necrosis-Factor
Protein-Kinase-C
Medicinal-Plants
Q-Index Code C1
Q-Index Status Provisional Code
Grant ID M1086
23097
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collection: School of Biomedical Sciences Publications
 
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Created: Mon, 13 Nov 2017, 12:53:13 EST