Modeling linkage disequilibrium in natural populations: The example of the Soay sheep population of St. Kilda, Scotland

McRae, AF, Pemberton, JM and Visscher, PM (2005) Modeling linkage disequilibrium in natural populations: The example of the Soay sheep population of St. Kilda, Scotland. Genetics, 171 1: 251-258. doi:10.1534/genetics.105.040972


Author McRae, AF
Pemberton, JM
Visscher, PM
Title Modeling linkage disequilibrium in natural populations: The example of the Soay sheep population of St. Kilda, Scotland
Journal name Genetics   Check publisher's open access policy
ISSN 0016-6731
Publication date 2005-09-01
Year available 2005
Sub-type Article (original research)
DOI 10.1534/genetics.105.040972
Open Access Status Not yet assessed
Volume 171
Issue 1
Start page 251
End page 258
Total pages 8
Place of publication BALTIMORE
Publisher GENETICS
Language eng
Abstract The use of linkage disequilibrium to localize the genes underlying quantitative traits has received considerable attention in the livestock genetics community over the past few years. This has resulted in the investigation of linkage disequilibrium structures of several domestic livestock populations to assess their potential use in fine-mapping efforts. However, the linkage disequilibrium structure of free-living populations has been less well investigated. As the direct evaluation of linkage disequilibrium can be both time consuming and expensive the use of simulations that include as many aspects of population history as possible is advocated as an alternative. A simulation of the linkage disequilibrium structure of the Soay sheep population of St. Kilda, Scotland, is provided as an example. The simulated population showed significant decline of linkage disequilibrium with genetic distance and low levels of background linkage disequilibrium, indicating that the Soay sheep population is a viable resource for linkage disequilibrium fine mapping of quantitative trait loci.
Keyword Quantitative Trait Loci
Deer Cervus-Elaphus
Dairy-Cattle
Genome
Selection
Humans
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collection: WoS Import - Archived
 
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Created: Mon, 13 Nov 2017, 08:09:40 EST