CDX2, a human homologue of Drosophila caudal, is mutated in both alleles in a replication error positive colorectal cancer

Wicking, C, Simms, LA, Evans, T, Walsh, M, Chawengsaksophak, K, Beck, F, Chenevix-Trench, G, Young, J, Jass, J, Leggett, B and Wainwright, B (1998) CDX2, a human homologue of Drosophila caudal, is mutated in both alleles in a replication error positive colorectal cancer. Oncogene, 17 5: 657-659. doi:10.1038/sj.onc.1201971


Author Wicking, C
Simms, LA
Evans, T
Walsh, M
Chawengsaksophak, K
Beck, F
Chenevix-Trench, G
Young, J
Jass, J
Leggett, B
Wainwright, B
Title CDX2, a human homologue of Drosophila caudal, is mutated in both alleles in a replication error positive colorectal cancer
Journal name Oncogene   Check publisher's open access policy
ISSN 0950-9232
Publication date 1998-08-06
Year available 1998
Sub-type Article (original research)
DOI 10.1038/sj.onc.1201971
Open Access Status Not yet assessed
Volume 17
Issue 5
Start page 657
End page 659
Total pages 3
Place of publication BASINGSTOKE
Publisher STOCKTON PRESS
Language eng
Abstract The Cdx2 gene is one of three murine homologues of the Drosophila homeobox gene caudal, Mice heterozygous for a null mutation in Cdx2 exhibit a variable phenotype including tail abnormalities, stunted growth and a homeotic shift of vertebrae. Most strikingly, however, 90% of heterozygous mice were reported to develop multiple intestinal adenomatous polyps, most notably in the proximal colon (Chawengsaksophak et al., 1997). These observations led us to propose that mutation of CDX2 may be involved in the genesis of some human colorectal tumours, A survey of DNA from 85 colorectal tumours revealed that one with extensive microsatellite instability (RER+ phenotype) has mutations in both alleles of CDX2, Both mutations occur in coding regions which contain repetitive elements and are consistent with those found in RER+ tumours.
Keyword Microsatellite Instability
Expression
Carcinoma
Receptor
Mucin
Gene
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: WoS Import - Archived
 
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Created: Sun, 12 Nov 2017, 09:42:29 EST