Clinical review: adiponectin biology and its role in inflammation and critical illness

Robinson, Katherine, Prins, John and Venkatesh, Bala (2011) Clinical review: adiponectin biology and its role in inflammation and critical illness. Critical Care, 15 2: . doi:10.1186/cc10021


Author Robinson, Katherine
Prins, John
Venkatesh, Bala
Title Clinical review: adiponectin biology and its role in inflammation and critical illness
Journal name Critical Care   Check publisher's open access policy
ISSN 1466-609X
1364-8535
Publication date 2011-04-20
Year available 2011
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1186/cc10021
Open Access Status DOI
Volume 15
Issue 2
Total pages 9
Place of publication London, United Kingdom
Publisher BioMed Central
Language eng
Abstract Adiponectin is an adipokine first described just over a decade ago. Produced almost exclusively by adipocytes, adiponectin circulates in high concentrations in human plasma. Research into this hormone has revealed it to have insulin-sensitizing, anti-inflammatory and cardioprotective roles. This review discusses the history, biology and physiological role of adiponectin and explores its role in disease, with specific focus on adiponectin in inflammation and sepsis. It appears that an inverse relationship exists between adiponectin and inflammatory cytokines. Low levels of adiponectin have been found in critically ill patients, although data are limited in human subjects at this stage. The role of adiponectin in systemic inflammation and critical illness is not well defined. Early data suggest that plasma levels of adiponectin are decreased in critical illness. Whether this is a result of the disease process itself or whether patients with lower levels of this hormone are more susceptible to developing a critical illness is not known. This observation of lower adiponectin levels then raises the possibility of therapeutic options to increase circulating adiponectin levels. The various options for modulation of serum adiponectin (recombinant adiponectin, thiazolidinediones) are discussed.
Keyword Nf-Kappa-B
Molecular-Weight Adiponectin
Vascular Endothelial-Cells
Activated Protein-Kinase
Adipose-Specific Gene
Necrosis-Factor-Alpha
Fatty-Acid Oxidation
Insulin-Resistance
Metabolic Syndrome
Plasma-Protein
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: Mater Research Institute-UQ (MRI-UQ)
School of Medicine Publications
 
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Created: Sun, 12 Nov 2017, 07:19:28 EST