Venom peptides as therapeutics: advances, challenges and the future of venom-peptide discovery

Robinson, Samuel D., Undheim, Eivind A. B., Ueberheide, Beatrix and King, Glenn F. (2017) Venom peptides as therapeutics: advances, challenges and the future of venom-peptide discovery. Expert Review of Proteomics, 14 10: 931-939. doi:10.1080/14789450.2017.1377613


Author Robinson, Samuel D.
Undheim, Eivind A. B.
Ueberheide, Beatrix
King, Glenn F.
Title Venom peptides as therapeutics: advances, challenges and the future of venom-peptide discovery
Journal name Expert Review of Proteomics   Check publisher's open access policy
ISSN 1478-9450
Publication date 2017-01-01
Year available 2017
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1080/14789450.2017.1377613
Open Access Status Not yet assessed
Volume 14
Issue 10
Start page 931
End page 939
Total pages 9
Place of publication ABINGDON
Publisher TAYLOR & FRANCIS LTD
Language eng
Abstract Introduction: Animal venoms are complex chemical arsenals. Most venoms are rich in bioactive peptides with proven potential as research tools, drug leads and drugs.Areas covered: We review recent advances in venom-peptide discovery, particularly the adoption of combined transcriptomic/proteomic approaches for the exploration of venom composition.Expert commentary: Advances in transcriptomics and proteomics have dramatically altered the manner and rate of venom-peptide discovery. The increasing trend towards a toxin-driven approach, as opposed to traditional target-based screening of venoms, is likely to expedite the discovery of venom-peptides with novel structures and new and unanticipated mechanisms of action. At the same time, these advances will drive the development of higher-throughput approaches for target identification. Taken together, these approaches should enhance our understanding of the natural ecological function of venom peptides and increase the rate of identification of novel venom-derived pharmacological tools, drug leads and drugs.
Keyword D-Amino-Acid
Conus-Geographus Venom
Percutaneous Coronary Intervention
Mass-Spectrometric Determination
Electron-Transfer Dissociation
Disulfide Connectivity
Spider-Venom
Drug Discovery
Snail Venom
D-Serine
Q-Index Code C1
Q-Index Status Provisional Code
Grant ID DP160104025
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collection: WoS Import
 
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Created: Sat, 11 Nov 2017, 23:08:41 EST