In vitro dissolution, cellular membrane permeability and anti-inflammatory response of resveratrol-encapsulated mesoporous silica nanoparticles

Juere, Estelle, Florek, Justyna, Bouchoucha, Meryem, Jambhnukar, Siddharth, Wong, Kuan Yau, Popat, Amirali and Kleitz, Freddy (2017) In vitro dissolution, cellular membrane permeability and anti-inflammatory response of resveratrol-encapsulated mesoporous silica nanoparticles. Molecular Pharmaceutics, 14 12: 4431-4441. doi:10.1021/acs.molpharmaceut.7b00529


Author Juere, Estelle
Florek, Justyna
Bouchoucha, Meryem
Jambhnukar, Siddharth
Wong, Kuan Yau
Popat, Amirali
Kleitz, Freddy
Title In vitro dissolution, cellular membrane permeability and anti-inflammatory response of resveratrol-encapsulated mesoporous silica nanoparticles
Formatted title
In vitro dissolution, cellular membrane permeability and anti-inflammatory response of resveratrol-encapsulated mesoporous silica nanoparticles
Journal name Molecular Pharmaceutics   Check publisher's open access policy
ISSN 1543-8384
1543-8392
Publication date 2017-11-02
Year available 2017
Sub-type Article (original research)
DOI 10.1021/acs.molpharmaceut.7b00529
Open Access Status Not yet assessed
Volume 14
Issue 12
Start page 4431
End page 4441
Total pages 38
Place of publication Washington, DC, United States
Publisher American Chemical Society
Language eng
Subject 1313 Molecular Medicine
3003 Pharmaceutical Science
3002 Drug Discovery
Abstract Sizing drugs down to the submicron and nanometer scale using nanoparticles has been extensively used in pharmaceutical industries to overcome the poor aqueous solubility of potential :therapeutic agents. Here, we report the encapsulation and release of resveratrol, a promising anti-inflammatory and anticancer nutraceutical, from the mesopores of MCM-48-type silica nanospheres of various particle sizes, i.e., 90, 150, and 300 nm. Furthermore, the influence of the carrier pore size on drug solubility was also evaluated (3.5 vs 7 nm). From our results, it is observed that the saturated solubility could depend not only on the pore size but also on the particle size of the nanocarriers. Moreover, with our resveratrol-mesoporous silica nanoparticles formulation, we have observed that the permeability of resveratrol encapsulated in MCM-48 nanoparticles (90 nm) can be enhanced compared to a resveratrol suspension when tested through the human colon carcinoma cell monolayer (Caco-2). Using an in vitro NF-kappa B assay, we showed that resveratrol encapsulation did not alter its bioactivity and, at lower concentration, i.e., 5 mu g mL(-1), resveratrol encapsulation provided higher anti-inflammatory activity compared to both resveratrol suspension and solution. All combined, the reported results dearly highlight the potential of small size mesoporous silica nanoparticles as next generation nanocarriers for hydrophobic drugs and nutraceuticals.
Keyword Enhanced Colloidal Stability
Water-Soluble Drugs
Oral Bioavailability
Facile Synthesis
Amorphous Drug
Delivery
Solubility
Release
Size
Ph
Q-Index Code C1
Q-Index Status Provisional Code
Grant ID RGPIN-2014-05821
1107836
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: HERDC Pre-Audit
School of Pharmacy Publications
 
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Created: Tue, 07 Nov 2017, 08:06:54 EST by Mr Amirali Popat on behalf of School of Pharmacy