A multi-scale model for hair follicles reveals heterogeneous domains driving rapid spatiotemporal hair growth patterning

Wang, Qixuan, Oh, Ji Won, Lee, Hye-Lim, Dhar, Anukriti, Peng, Tao, Ramos, Raul, Guerrero-Juarez, Christian Fernando, Wang, Xiaojie, Zhao, Ran, Cao, Xiaoling, Le, Jonathan, Fuentes, Melisa A., Jocoy, Shelby C, Rossi, Antoni R, Vu, Brian, Pham, Kim, Wang, Xiaoyang, Mali, Nanda Maya, Park, Jung Min, Choi, June-Hyug, Lee, Hyunsu, Legrand, Julien M. D., Kandyba, Eve, Kim, Jung Chul, Kim, Moonkyu, Foley, John, Yu, Zhengquan, Kobielak, Krzysztof, Andersen, Bogi, Khosrotehrani, Kiarash, Nie, Qing and Plikus, Maksim V. (2017) A multi-scale model for hair follicles reveals heterogeneous domains driving rapid spatiotemporal hair growth patterning. Elife, 6 . doi:10.7554/eLife.22772


Author Wang, Qixuan
Oh, Ji Won
Lee, Hye-Lim
Dhar, Anukriti
Peng, Tao
Ramos, Raul
Guerrero-Juarez, Christian Fernando
Wang, Xiaojie
Zhao, Ran
Cao, Xiaoling
Le, Jonathan
Fuentes, Melisa A.
Jocoy, Shelby C
Rossi, Antoni R
Vu, Brian
Pham, Kim
Wang, Xiaoyang
Mali, Nanda Maya
Park, Jung Min
Choi, June-Hyug
Lee, Hyunsu
Legrand, Julien M. D.
Kandyba, Eve
Kim, Jung Chul
Kim, Moonkyu
Foley, John
Yu, Zhengquan
Kobielak, Krzysztof
Andersen, Bogi
Khosrotehrani, Kiarash
Nie, Qing
Plikus, Maksim V.
Title A multi-scale model for hair follicles reveals heterogeneous domains driving rapid spatiotemporal hair growth patterning
Journal name Elife   Check publisher's open access policy
ISSN 2050-084X
Publication date 2017-07-11
Year available 2017
Sub-type Article (original research)
DOI 10.7554/eLife.22772
Open Access Status DOI
Volume 6
Total pages 7
Place of publication Cambridge, United Kingdom
Publisher eLife Sciences Publications
Language eng
Subject 2800 Neuroscience
1300 Biochemistry, Genetics and Molecular Biology
2400 Immunology and Microbiology
Abstract The control principles behind robust cyclic regeneration of hair follicles (HFs) remain unclear. Using multi-scale modeling, we show that coupling inhibitors and activators with physical growth of HFs is sufficient to drive periodicity and excitability of hair regeneration. Model simulations and experimental data reveal that mouse skin behaves as a heterogeneous regenerative field, composed of anatomical domains where HFs have distinct cycling dynamics. Interactions between fast-cycling chin and ventral HFs and slow-cycling dorsal HFs produce bilaterally symmetric patterns. Ear skin behaves as a hyper-refractory domain with HFs in extended rest phase. Such hyper-refractivity relates to high levels of BMP ligands and WNT antagonists, in part expressed by ear-specific cartilage and muscle. Hair growth stops at the boundaries with hyper-refractory ears and anatomically discontinuous eyelids, generating wave-breaking effects. We posit that similar mechanisms for coupled regeneration with dominant activator, hyper-refractory, and wave-breaker regions can operate in other actively renewing organs.
Keyword Stem-Cell Activation
Cycle Clock
Dermal Papilla
In-Vivo
Regression Catagen
Skin
Regeneration
Niche
Induction
Dynamics
Q-Index Code C1
Q-Index Status Provisional Code
Grant ID 2016R1C1B1015211
T32-CA009054
DGE-1321846
GM055246
R01-AR061552
1023371
00029641
R01-AR069653
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: HERDC Pre-Audit
UQ Diamantina Institute Publications
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Created: Sun, 05 Nov 2017, 09:42:06 EST