Nitroimidazoles: Molecular Fireworks That Combat a Broad Spectrum of Infectious Diseases

Ang, Chee Wei, Jarrad, Angie M., Cooper, Matthew A. and Blaskovich, Mark A. T. (2017) Nitroimidazoles: Molecular Fireworks That Combat a Broad Spectrum of Infectious Diseases. Journal of Medicinal Chemistry, 60 18: 7636-7657. doi:10.1021/acs.jmedchem.7b00143


Author Ang, Chee Wei
Jarrad, Angie M.
Cooper, Matthew A.
Blaskovich, Mark A. T.
Title Nitroimidazoles: Molecular Fireworks That Combat a Broad Spectrum of Infectious Diseases
Journal name Journal of Medicinal Chemistry   Check publisher's open access policy
ISSN 0022-2623
Publication date 2017-09-28
Year available 2017
Sub-type Article (original research)
DOI 10.1021/acs.jmedchem.7b00143
Open Access Status Not yet assessed
Volume 60
Issue 18
Start page 7636
End page 7657
Total pages 22
Place of publication WASHINGTON
Publisher AMER CHEMICAL SOC
Language eng
Abstract Infectious diseases claim millions of lives every year, but with the advent of drug resistance, therapeutic options to treat infections are inadequate. There is now an urgent need to develop new and effective treatments. Nitroimidazoles are a class of antimicrobial drugs that have remarkable broad spectrum activity against parasites, mycobacteria, and anaerobic Gram-positive and Gram-negative bacteria. While nitroimidazoles were discovered in the 1950s, there has been renewed interest in their therapeutic potential, particularly for the treatment of parasitic infections and tuberculosis. In this review, we summarize different classes of nitroimidazoles that have been described in the literature in the past five years, from approved drugs and clinical candidates to examples undergoing preclinical or early stage development. The relatively "nonspecific" mode of action and resistance mechanisms of nitromidazoles are discussed, and contemporary strategies to facilitate nitroimidazole drug development are highlighted.
Keyword Human African Trypanosomiasis
Neglected Tropical Diseases
Helicobacter-Pylori Infection
Drug-Resistant Tuberculosis
Potential Oral Treatment
Chronic Chagas-Disease
In-Vivo Activities
Trichomonas-Vaginalis
Mycobacterium-Tuberculosis
Clostridium-Difficile
Q-Index Code C1
Q-Index Status Provisional Code
Grant ID APP1059354
WT1104797/Z/14/Z
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: WoS Import
 
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Created: Sun, 05 Nov 2017, 09:35:27 EST