Nanoformulations of albendazole as effective anticancer and antiparasite agents

Movahedi, Fatemeh, Li, Li, Gu, Wenyi and Xu, Zhi Ping (2017) Nanoformulations of albendazole as effective anticancer and antiparasite agents. Nanomedicine, 12 20: 2555-2574. doi:10.2217/nnm-2017-0102


Author Movahedi, Fatemeh
Li, Li
Gu, Wenyi
Xu, Zhi Ping
Title Nanoformulations of albendazole as effective anticancer and antiparasite agents
Journal name Nanomedicine   Check publisher's open access policy
ISSN 1743-5889
1748-6963
Publication date 2017-09-28
Year available 2017
Sub-type Critical review of research, literature review, critical commentary
DOI 10.2217/nnm-2017-0102
Open Access Status Not yet assessed
Volume 12
Issue 20
Start page 2555
End page 2574
Total pages 20
Place of publication London, United Kingdom
Publisher FUTURE MEDICINE
Language eng
Subject 1502 Bioengineering
2701 Medicine (miscellaneous)
2204 Biomedical Engineering
2500 Materials Science
Abstract Initially emerging as a widely used clinical antiparasitic drug, albendazole (ABZ) has been increasingly recognized as an effective anticancer agent due to its outstanding advantage, in other words, low toxicity to normal cells but high effectiveness against parasites and some tumors. The major challenge is its poor water solubility and subsequently low bioavailability. This article thus first reviews the brief achievements in using ABZ to treat parasites and cancers, and summarizes the basic mechanisms of action of ABZ. Then this article critically reviews recent nanotechnological strategies, in other words, formulating/conjugating it with carriers into nanoformulations, in practices of improving aqueous solubility and efficacy in treatment of tumors and parasites. Our expert opinions in this field are provided for more effective delivery of ABZ to treat tumors and parasites in vivo.
Keyword Endothelial Growth-Factor
Hydroxypropyl-Beta-Cyclodextrin
Solid Lipid Nanoparticles
Drug-Delivery Systems
Ovarian-Cancer Cells
In-Vitro
Tubulin Polymerization
Albumin Nanoparticles
Malignant Ascites
Nude-Mice
Q-Index Code C1
Q-Index Status Provisional Code
Grant ID FT120100813
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: HERDC Pre-Audit
Australian Institute for Bioengineering and Nanotechnology Publications
 
Versions
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 0 times in Thomson Reuters Web of Science Article
Scopus Citation Count Cited 0 times in Scopus Article
Google Scholar Search Google Scholar
Created: Sun, 05 Nov 2017, 09:35:02 EST