Deficient double-strand break repair in oral squamous cell carcinoma cell lines

Jessri, Maryam, Dalley, Andrew J. and Farah, Camile S. (2017) Deficient double-strand break repair in oral squamous cell carcinoma cell lines. Journal of Oral Pathology & Medicine, 46 9: 695-702. doi:10.1111/jop.12576


Author Jessri, Maryam
Dalley, Andrew J.
Farah, Camile S.
Title Deficient double-strand break repair in oral squamous cell carcinoma cell lines
Journal name Journal of Oral Pathology & Medicine   Check publisher's open access policy
ISSN 0904-2512
Publication date 2017-10-01
Year available 2017
Sub-type Article (original research)
DOI 10.1111/jop.12576
Open Access Status Not yet assessed
Volume 46
Issue 9
Start page 695
End page 702
Total pages 8
Place of publication HOBOKEN
Publisher WILEY
Language eng
Abstract Background: Approximately 20% of oral squamous cell carcinoma (OSCC) cases arise without any identifiable environmental cause, suggesting involvement of genetic influences in their aetiology. DNA double-strand breaks (DSBs) sever both strands of DNA and pose a potential threat to genomic integrity. A hastened accumulation of somatic mutations consequent to DSB repair is deemed to be a likely event in tumorigenesis of OSCC.
Keyword Dna Covalent Complexes
Expression
Cancer
Model
Nbs1
Q-Index Code C1
Q-Index Status Provisional Code
Grant ID 102/2010
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: WoS Import
 
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Created: Sun, 05 Nov 2017, 09:30:43 EST