A mitochondria-targeted ratiometric probe for the fluorescent and colorimetric detection of SO2 derivatives in live cells

Wang, Yongfei, Meng, Qingtao, Zhang, Run, Jia, Hongmin, Wang, Cuiping and Zhang, Zhiqiang (2017) A mitochondria-targeted ratiometric probe for the fluorescent and colorimetric detection of SO2 derivatives in live cells. Journal of Luminescence, 192 297-302. doi:10.1016/j.jlumin.2017.06.033

Attached Files (Some files may be inaccessible until you login with your UQ eSpace credentials)
Name Description MIMEType Size Downloads
UQ692235_OA.pdf Full text (open access) application/pdf 1.11MB 0

Author Wang, Yongfei
Meng, Qingtao
Zhang, Run
Jia, Hongmin
Wang, Cuiping
Zhang, Zhiqiang
Title A mitochondria-targeted ratiometric probe for the fluorescent and colorimetric detection of SO2 derivatives in live cells
Journal name Journal of Luminescence   Check publisher's open access policy
ISSN 0022-2313
1872-7883
Publication date 2017-06-19
Year available 2017
Sub-type Article (original research)
DOI 10.1016/j.jlumin.2017.06.033
Open Access Status File (Author Post-print)
Volume 192
Start page 297
End page 302
Total pages 6
Place of publication Amsterdam, The Netherlands
Publisher Elsevier
Language eng
Subject 1304 Biophysics
3107 Atomic and Molecular Physics, and Optics
1600 Chemistry
1303 Biochemistry
3104 Condensed Matter Physics
Abstract An abnormal endogenous SO2 level can induce toxicological effects leading to cancer, cardiovascular diseases, and neurological disorders, as they involve in various physiology and pathological processes in mitochondria cell apparatus. In this study, we report a ratiometric fluorescent probe (NAB-Id) based on the cyanine dye for the detection of sulfur dioxide (SO2) derivatives in aqueous media and live cells. Upon the addition of SO2 derivatives (SO32-/HSO3-) to the solution of NAB-Id, led to the nucleophilic addition to the polymethine, resulting in dramatic colorimetric and fluorescence dual responses. NAB-Id responses to HSO3- with low detection limit (58.6 nM), outstanding specificity (without the interfering of H2S), fast response (t(1/2) = 30 s) and working well at physiological pH. Fluorescence co-localization studies demonstrated that NAB-Id was a mitochondria-targeted fluorescent probe for the real-time sensing and bioimaging of SO2 derivatives in living cells.
Keyword Sulfur-Dioxide Derivatives
Living Cells
Aqueous-Solution
Selective Detection
Cancer-Cells
Air-Pollution
In-Vivo
Sulfite
Bisulfite
Chemosensor
Q-Index Code C1
Q-Index Status Provisional Code
Grant ID 21542017
201602400
ARC DE170100092
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: HERDC Pre-Audit
Australian Institute for Bioengineering and Nanotechnology Publications
 
Versions
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 0 times in Thomson Reuters Web of Science Article
Scopus Citation Count Cited 1 times in Scopus Article | Citations
Google Scholar Search Google Scholar
Created: Sun, 05 Nov 2017, 09:08:24 EST